Letter to the Editor

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Blood Res 2017; 52(4):

Published online December 31, 2017

https://doi.org/10.5045/br.2017.52.4.324

© The Korean Society of Hematology

A case of primary plasma cell leukemia exhibiting hemophagocytic plasma cells relapsed with multiple cutaneous plasmacytoma

Narae Hwang, Ji Yeon Ham, and Jang Soo Suh*

Department of Clinical Pathology, Kyungpook National University School of Medicine, Daegu, Korea.

Correspondence to : Jang Soo Suh. Department of Clinical Pathology, Kyungpook National University School of Medicine, 680 Gukchebosang-ro, Chung-gu, Daegu 41944, Korea. suhjs@knu.ac.kr

Received: May 22, 2017; Revised: June 1, 2017; Accepted: July 13, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

Hemophagocytic plasma cells and abnormal karyotyping result. (A) Microscopic examination of bone marrow (BM) showing large, bizarre plasma cells with characteristic hemophagocytic features mostly with mature erythrocytes and platelets (Wright-Giemsa staining, ×1,000). (B) Conventional BM chromosome analysis result showing 45,X,−X,+1,dic(1;8)(p13;p23),del(6)(q22q25), del(8)(p21) karyotype.


Fig. 2.

Multiple skin nodules and their biopsy showing infiltration of plasma cells. Multiple skin nodules in the patient's extremities (A). Biopsy of the skin-infiltrating plasma cells showing positive immunohistochemical staining for CD138 (B) and lambda light-chain (C) (×200).


  1. Deng, S, Xu, Y, An, G, et al. Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases. Clin Lymphoma Myeloma Leuk, 2015;15;286-291.
    Pubmed
  2. Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press.
  3. Invernizzi, R, Pecci, A. A case of phagocytic multiple myeloma. Haematologica, 2000;85;318.
    Pubmed
  4. Kanoh, T, Saigo, K. Phagocytic myeloma cells in asymptomatic multiple myeloma. Tohoku J Exp Med, 1987;153;207-210.
    Pubmed
  5. Kucukkaya, RD, Hacihanefioglu, A, Yenerel, MN, et al. CD15-expressing phagocytic plasma cells in a patient with multiple myeloma. Blood, 2001;97;581-583.
    Pubmed
  6. Ludwig, H, Pavelka, M. Phagocytic plasma cells in a patient with multiple myeloma. Blood, 1980;56;173-176.
    Pubmed
  7. Ramos, J, Lorsbach, R. Hemophagocytosis by neoplastic plasma cells in multiple myeloma. Blood, 2014;123;1634.
    Pubmed
  8. Savage, DG, Zipin, D, Bhagat, G, Alobeid, B. Hemophagocytic, non-secretory multiple myeloma. Leuk Lymphoma, 2004;45;1061-1064.
    Pubmed
  9. Fernández, de, Kyle, RA, Durie, BG, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia, 2013;27;780-791.
    Pubmed
  10. Jurczyszyn, A, Olszewska-Szopa, M, Hungria, V, et al. Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients. Leuk Lymphoma, 2016;57;2071-2076.
    Pubmed
  11. Requena, L, Kutzner, H, Palmedo, G, et al. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol, 2003;139;475-486.
    Pubmed

Article

Letter to the Editor

Blood Res 2017; 52(4): 324-326

Published online December 31, 2017 https://doi.org/10.5045/br.2017.52.4.324

Copyright © The Korean Society of Hematology.

A case of primary plasma cell leukemia exhibiting hemophagocytic plasma cells relapsed with multiple cutaneous plasmacytoma

Narae Hwang, Ji Yeon Ham, and Jang Soo Suh*

Department of Clinical Pathology, Kyungpook National University School of Medicine, Daegu, Korea.

Correspondence to:Jang Soo Suh. Department of Clinical Pathology, Kyungpook National University School of Medicine, 680 Gukchebosang-ro, Chung-gu, Daegu 41944, Korea. suhjs@knu.ac.kr

Received: May 22, 2017; Revised: June 1, 2017; Accepted: July 13, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    Hemophagocytic plasma cells and abnormal karyotyping result. (A) Microscopic examination of bone marrow (BM) showing large, bizarre plasma cells with characteristic hemophagocytic features mostly with mature erythrocytes and platelets (Wright-Giemsa staining, ×1,000). (B) Conventional BM chromosome analysis result showing 45,X,−X,+1,dic(1;8)(p13;p23),del(6)(q22q25), del(8)(p21) karyotype.

    Blood Research 2017; 52: 324-326https://doi.org/10.5045/br.2017.52.4.324

    Fig 2.

    Figure 2.

    Multiple skin nodules and their biopsy showing infiltration of plasma cells. Multiple skin nodules in the patient's extremities (A). Biopsy of the skin-infiltrating plasma cells showing positive immunohistochemical staining for CD138 (B) and lambda light-chain (C) (×200).

    Blood Research 2017; 52: 324-326https://doi.org/10.5045/br.2017.52.4.324

    References

    1. Deng, S, Xu, Y, An, G, et al. Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases. Clin Lymphoma Myeloma Leuk, 2015;15;286-291.
      Pubmed
    2. Swerdlow SH, Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press.
    3. Invernizzi, R, Pecci, A. A case of phagocytic multiple myeloma. Haematologica, 2000;85;318.
      Pubmed
    4. Kanoh, T, Saigo, K. Phagocytic myeloma cells in asymptomatic multiple myeloma. Tohoku J Exp Med, 1987;153;207-210.
      Pubmed
    5. Kucukkaya, RD, Hacihanefioglu, A, Yenerel, MN, et al. CD15-expressing phagocytic plasma cells in a patient with multiple myeloma. Blood, 2001;97;581-583.
      Pubmed
    6. Ludwig, H, Pavelka, M. Phagocytic plasma cells in a patient with multiple myeloma. Blood, 1980;56;173-176.
      Pubmed
    7. Ramos, J, Lorsbach, R. Hemophagocytosis by neoplastic plasma cells in multiple myeloma. Blood, 2014;123;1634.
      Pubmed
    8. Savage, DG, Zipin, D, Bhagat, G, Alobeid, B. Hemophagocytic, non-secretory multiple myeloma. Leuk Lymphoma, 2004;45;1061-1064.
      Pubmed
    9. Fernández, de, Kyle, RA, Durie, BG, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia, 2013;27;780-791.
      Pubmed
    10. Jurczyszyn, A, Olszewska-Szopa, M, Hungria, V, et al. Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients. Leuk Lymphoma, 2016;57;2071-2076.
      Pubmed
    11. Requena, L, Kutzner, H, Palmedo, G, et al. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol, 2003;139;475-486.
      Pubmed
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