Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review

Karthik Bommannan; Man Updesh Singh Sachdeva; Aravind Sekar; Rajender Kumar; Pranab Dey

doi:10.5045/br.2017.52.3.227

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Blood Res 2017; 52(3):

Published online September 25, 2017

https://doi.org/10.5045/br.2017.52.3.227

Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review

Karthik Bommannan¹, Man Updesh Singh Sachdeva^1*, Aravind Sekar², Rajender Kumar³, and Pranab Dey²

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¹Department of Hematology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

²Department of Cytopathology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

³Department of Nuclear Medicine, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Correspondence to : Man Updesh Singh Sachdeva. Department of Hematology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh 160012, India. drmanupdeshpgi@yahoo.co.in, drmanupdesh@gmail.com

Received: December 8, 2016; Revised: January 2, 2017; Accepted: March 16, 2017

Article

Letter to the Editor

Blood Res 2017; 52(3): 227-229

Published online September 25, 2017 https://doi.org/10.5045/br.2017.52.3.227

Primary adrenal T-cell lymphoma in a young adult presented with pseudo-hypopyon: a case report and literature review

Karthik Bommannan¹, Man Updesh Singh Sachdeva^1*, Aravind Sekar², Rajender Kumar³, and Pranab Dey²

¹Department of Hematology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

²Department of Cytopathology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

³Department of Nuclear Medicine, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Correspondence to:Man Updesh Singh Sachdeva. Department of Hematology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh 160012, India. drmanupdeshpgi@yahoo.co.in, drmanupdesh@gmail.com

Received: December 8, 2016; Revised: January 2, 2017; Accepted: March 16, 2017

Fig 1.

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Figure 1.

Microscopic findings, immunohistochemical staining, and whole-body fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) of primary adrenal T-cell lymphoma. (A) Aqueous humor aspiration showed infiltration of atypical lymphoid cells. (B) Bone marrow (BM) aspiration showed infiltration of atypical lymphoid cells with irregular nuclear membrane, coarse chromatin, basophilic cytoplasm and fine azurophilic granules. (C) BM biopsy showed infiltration of lymphoma cells with “fried egg” pattern. (D) FDG avid lesions in the adrenal glands. (E) Diffuse FDG uptake in the BM. (F) Absence of FDG avid intra-orbital and intra-ocular mass lesions. (G) Adrenal aspiration showed lymphoma infiltration. (H) CD34 immunohistochemistry (IHC) of the BM biopsy highlighting intra-sinusoidal pattern. (I) CD8 positivity in the BM lymphoid infiltrate. (J, K) Diffuse and intense FDG uptake in both the adrenal glands (A, B, & G: May-Grünwald Giemsa stain; C: Hematoxylin and eosin stain).

Blood Research 2017; 52: 227-229https://doi.org/10.5045/br.2017.52.3.227

Table 1 . Review of clinical and radiologic findings in patients with primary adrenal T-cell lymphoma..

Abbreviations: CHOP, Cyclophosphamide 750 mg/m² per day, vincristine 2 mg per cycle, doxorubicin 50 mg/m² per cycle, prednisone 60 mg per day; CNS, central nervous system; CSF, cerebrospinal fluid; IVC, Inferior vena cava; NA, not available..