An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma

So Yeon Hwang; In Sook Woo; Yosep Chong; Chang Suk Kang; Chi Wha Han; Yun Hwa Jung

doi:10.5045/br.2017.52.3.224

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Blood Res 2017; 52(3):

Published online September 25, 2017

https://doi.org/10.5045/br.2017.52.3.224

An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma

So Yeon Hwang^1*, In Sook Woo¹, Yosep Chong², Chang Suk Kang², Chi Wha Han³, and Yun Hwa Jung¹

Author Info. +

¹Division of Medical Oncology, Department of Internal Medicine, Yeouido St Mary's Hospital, College of Medicine, The Catholic University of Korea.

²Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

³Division of Hematology-Oncology, Department of Internal Medicine, Cheju Halla General Hospital, Jeju, Korea.

Correspondence to : So Yeon Hwang. Division of Medical Oncology, Department of Internal Medicine, Yeouido St Mary's Hospital, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea. yeony86@hanmail.net

Received: October 9, 2016; Revised: October 18, 2016; Accepted: January 17, 2017

Article

Letter to the Editor

Blood Res 2017; 52(3): 224-227

Published online September 25, 2017 https://doi.org/10.5045/br.2017.52.3.224

An unusual case of metachronous NK/T cell lymphoma and interdigitating dendritic cell sarcoma

So Yeon Hwang^1*, In Sook Woo¹, Yosep Chong², Chang Suk Kang², Chi Wha Han³, and Yun Hwa Jung¹

¹Division of Medical Oncology, Department of Internal Medicine, Yeouido St Mary's Hospital, College of Medicine, The Catholic University of Korea.

²Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

³Division of Hematology-Oncology, Department of Internal Medicine, Cheju Halla General Hospital, Jeju, Korea.

Correspondence to:So Yeon Hwang. Division of Medical Oncology, Department of Internal Medicine, Yeouido St Mary's Hospital, 10 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea. yeony86@hanmail.net

Received: October 9, 2016; Revised: October 18, 2016; Accepted: January 17, 2017

Fig 1.

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Figure 1.

Abdominal CT image shows an approximately 4.5 cm-sized low-density mass-like lesion at the Lt external iliac nodal region (A). On sequentially performed PET-CT, increased FDG uptake was identified on the same lesion (B). Two months after diagnosis of NK/T cell lymphoma, follow-up PET-CT revealed extensive multiple hypermetabolic mass on areas including both lungs, spleen, and nasal cavity (C, D).

Blood Research 2017; 52: 224-227https://doi.org/10.5045/br.2017.52.3.224

Fig 2.

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Figure 2.

Histological findings of soft tissue show atypical T-cell proliferation with angiocentric pattern in (A) hematoxylin-eosin stain (×200), and (B) CD3 immunohistochemical (IHC) stain. Additional IHC staining of cancer cells shows positivity for granzyme (C), CD68 (D), and EBV (F) but negativity for CD1a (E). These findings are consistent with nasal type extranodal NK/T cell lymphoma.

Blood Research 2017; 52: 224-227https://doi.org/10.5045/br.2017.52.3.224

Fig 3.

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Figure 3.

Histological findings of cervical lymph node show spindle- to ovoid-shaped cells arranged intermingled with reactive lymphocytes in (A) hematoxylin-eosin stain (×200). IHC staining of cancer cells shows positivity for CD68 (B) and S100 (D) but negativity for CD1a (C) and EBV (F). Intermingled T-lymphocytes within IDCS show positivity for CD3 (E).

Blood Research 2017; 52: 224-227https://doi.org/10.5045/br.2017.52.3.224