Blood Res 2017; 52(2): 106-111  https://doi.org/10.5045/br.2017.52.2.106
Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
Mohammad Mehdi Akbarin1, Abbas Shirdel2, Alireza Bari2, Seyedeh Tahereh Mohaddes2, Houshang Rafatpanah1, Ehsan Ghayour Karimani3, Kobra Etminani4, Amin Golabpour4, and Reza Torshizi5

1Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

2Hematology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciencess, Mashhad, Iran.

3Molecular Diagnostic Unit, Research and Education Department, Razavi Hospitals, Mashhad, Iran.

4Department of Medical Informatics, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

5Department of Modern Sciences and Technologies, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.

Correspondence to: Reza Torshizi, Ph.D. Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan 91388-13944, Iran. torshiziR901@mums.ac.ir
Received: December 24, 2016; Revised: February 15, 2017; Accepted: March 14, 2017; Published online: June 22, 2017.
© The Korean Journal of Hematology. All rights reserved.

Abstract

Background

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL.

Methods

Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR.

Results

Significant differences in the mean expression levels of TAX and HBZ were observed between the two study groups (ATLL and AC, P=0.014 and P=0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P=0.047).

Conclusion

The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.

Keywords: HTLV-1, ATLL, TAX, HBZ, Proviral load


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