Blood Res 2017; 52(2):
Published online June 22, 2017
https://doi.org/10.5045/br.2017.52.2.106
© The Korean Society of Hematology
1Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
2Hematology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciencess, Mashhad, Iran.
3Molecular Diagnostic Unit, Research and Education Department, Razavi Hospitals, Mashhad, Iran.
4Department of Medical Informatics, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
5Department of Modern Sciences and Technologies, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
Correspondence to : Reza Torshizi, Ph.D. Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan 91388-13944, Iran. torshiziR901@mums.ac.ir
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the
Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of
Significant differences in the mean expression levels of
The HTLV-1 PVL and expression of
Keywords HTLV-1, ATLL,
Blood Res 2017; 52(2): 106-111
Published online June 22, 2017 https://doi.org/10.5045/br.2017.52.2.106
Copyright © The Korean Society of Hematology.
Mohammad Mehdi Akbarin1, Abbas Shirdel2, Alireza Bari2, Seyedeh Tahereh Mohaddes2, Houshang Rafatpanah1, Ehsan Ghayour Karimani3, Kobra Etminani4, Amin Golabpour4, and Reza Torshizi5
1Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
2Hematology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciencess, Mashhad, Iran.
3Molecular Diagnostic Unit, Research and Education Department, Razavi Hospitals, Mashhad, Iran.
4Department of Medical Informatics, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
5Department of Modern Sciences and Technologies, Molecular Medicine Department, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
Correspondence to:Reza Torshizi, Ph.D. Department of Modern Sciences and Technologies, Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan 91388-13944, Iran. torshiziR901@mums.ac.ir
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the
Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of
Significant differences in the mean expression levels of
The HTLV-1 PVL and expression of
Keywords: HTLV-1, ATLL,
Survival time of adult T-cell leukemia/lymphoma (ATLL) patients according to subtype.
Association between survival time and proviral load (PVL) in adult T-cell leukemia/lymphoma (ATLL) patients (five PVL groups were defined to examine the impact of HTLV-1 PVL on survival among patients with ATLL).
Table 1 . Primers and probes for
Table 2 . Clinical manifestations and survival time of adult T-cell leukemia/lymphoma (ATLL) patients..
Table 3 . TAX and HBZ expression in adult T-cell leukemia/lymphoma (ATLL) patients and asymptomatic carriers..
a)
Abbreviations: SD, standard deviation; SEM, standard error of the mean..
Survival time of adult T-cell leukemia/lymphoma (ATLL) patients according to subtype.
|@|~(^,^)~|@|Association between survival time and proviral load (PVL) in adult T-cell leukemia/lymphoma (ATLL) patients (five PVL groups were defined to examine the impact of HTLV-1 PVL on survival among patients with ATLL).