Therapy-related acute promyelocytic leukemia in plasma cell myeloma treated with melphalan: a case report and literature review

Hyunjung Gu; Young Jin Kim; Woo-In Lee; Juhee Lee; Hwi-Joong Yoon; Tae Sung Park

doi:10.5045/br.2017.52.1.62

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Letter to the Editor

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Blood Res 2017; 52(1):

Published online March 27, 2017

https://doi.org/10.5045/br.2017.52.1.62

Therapy-related acute promyelocytic leukemia in plasma cell myeloma treated with melphalan: a case report and literature review

Hyunjung Gu^1,#, Young Jin Kim^1,#, Woo-In Lee¹, Juhee Lee², Hwi-Joong Yoon³, and Tae Sung Park^1*

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¹Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.

²Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.

³Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.

Correspondence to : Tae Sung Park. Department of Laboratory Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. 153jesus@hanmail.net

Received: February 25, 2016; Revised: March 17, 2016; Accepted: March 28, 2016

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Letter to the Editor

Blood Res 2017; 52(1): 62-64

Published online March 27, 2017 https://doi.org/10.5045/br.2017.52.1.62

Therapy-related acute promyelocytic leukemia in plasma cell myeloma treated with melphalan: a case report and literature review

Hyunjung Gu^1,#, Young Jin Kim^1,#, Woo-In Lee¹, Juhee Lee², Hwi-Joong Yoon³, and Tae Sung Park^1*

¹Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.

²Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.

³Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.

Correspondence to: Tae Sung Park. Department of Laboratory Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. 153jesus@hanmail.net

Received: February 25, 2016; Revised: March 17, 2016; Accepted: March 28, 2016

Fig 1.

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Figure 1.

Microscopic examination of peripheral blood (PB) and bone marrow (BM) (A) PB shows rouleaux formation of red cells and an atypical promyelocyte. (B) BM aspiration smears shows an increased number of atypical promyelocytes with bilobed nuclei, densely packed large granules in cytoplasm and a few faggot cells (Wright-Giemsa stain ×1,000).

Blood Research 2017; 52: 62-64https://doi.org/10.5045/br.2017.52.1.62

Fig 2.

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Figure 2.

(A) Conventional bone marrow chromosome analysis showing 46,XX,t(15;17)(q22;q12). (B) Fluorescence in situ hybridizations for PML-RARA rearrangement showing two fusion signals [nuc ish (PML,RARA) ×3(RARA con PML ×2)].

Blood Research 2017; 52: 62-64https://doi.org/10.5045/br.2017.52.1.62

Table 1 . Cases of therapy-related acute promyelocytic leukemia in patients with plasma cell myeloma..

Abbreviations: ASCT, autologous stem cell transplantation; CT, chemotherapy; Ig, immunoglobulin; MM, multiple myeloma; MP, melphalanprednisolone therapy; ND, not described; RT, radiation therapy; VAD, doxorubicin+vincristine+cyclophosphamide; VP16, etoposide..