Blood Res 2017; 52(1):
Published online March 27, 2017
https://doi.org/10.5045/br.2017.52.1.50
© The Korean Society of Hematology
1Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
4Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Correspondence to : Seyed Hamidreza Monavari, Ph.D. Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Hemmat Exp. Way, Tehran, Iran. hrmonavari@yahoo.com
Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran.
This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay.
The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients.
In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.
Keywords Parvovirus B19, Genotype, Thalassemia, Iranian patients
Blood Res 2017; 52(1): 50-54
Published online March 27, 2017 https://doi.org/10.5045/br.2017.52.1.50
Copyright © The Korean Society of Hematology.
Seyed Ali Mohammad Arabzadeh1, Farideh Alizadeh1, Ahmad Tavakoli2, Hamidreza Mollaei1, Farah Bokharaei-Salim2, Gharib Karimi3, Mohammad Farahmand4, Helya Sadat Mortazavi2, and Seyed Hamidreza Monavari2*
1Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
3Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
4Department of Medical Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Correspondence to: Seyed Hamidreza Monavari, Ph.D. Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Hemmat Exp. Way, Tehran, Iran. hrmonavari@yahoo.com
Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran.
This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay.
The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients.
In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.
Keywords: Parvovirus B19, Genotype, Thalassemia, Iranian patients
Table 1 . Association between blood transfusion frequency and B19 infection..
a)Values are presented as numbers of subjects (percent). b)Values are presented as numbers of B19 infected patients..
Table 2 . Age distribution of patients with B19 infectiona)..
a)Values are presented as the numbers of subjects..
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