Letter to the Editor

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Blood Res 2015; 50(1):

Published online March 31, 2015

https://doi.org/10.5045/br.2015.50.1.55

© The Korean Society of Hematology

A case of pediatric ALL with t(16;21)(p11.2;q22) and FUS-ERG rearrangement

Mariela C. Coccé1*, Cristina N. Alonso2, Jorge Rossi3, Maria S. Felice2, Myriam R. Gitter2, and Marta S. Gallego1

1Servicio de Genética. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

2Servicio de Hemato-Oncología. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

3Servicio de Inmunología. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

Correspondence to : Mariela C. Coccé. Laboratorio de Citogenética, Servicio de Genética, Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Combate de los Pozos 1881, CP 1245, Buenos Aires, Argentina. marielacocce@yahoo.com.ar

Received: July 29, 2014; Revised: September 24, 2014; Accepted: February 12, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

Morphology of leukemic cells at diagnosis showing L1/L2 blasts.


Fig. 2.

(A) Partial karyotype showing a reciprocal translocation between 16p11.2 and 21q22; (B) Sequencing analysis of the RT-PCR product identifying a fusion between exon 7 of FUS and exon 6 of ERG.


  1. Huret, JL. t(16;21)(p11;q22). Atlas Genet Cytogenet Oncol Haematol, 2005;9;36-38.
  2. Ichikawa, H, Shimizu, K, Hayashi, Y, Ohki, M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res, 1994;54;2865-2868.
    Pubmed
  3. Liu, F, Gao, L, Jing, Y, et al. Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia. Leuk Lymphoma, 2013;54;1521-1526.
    Pubmed
  4. Heller, A, Loncarevic, IF, Glaser, M, et al. Breakpoint differentiation in chromosomal aberrations of hematological malignancies: Identification of 33 previously unrecorded breakpoints. Int J Oncol, 2004;24;127-136.
    Pubmed
  5. Kanazawa, T, Ogawa, C, Taketani, T, Taki, T, Hayashi, Y, Morikawa, A. TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease. Leuk Lymphoma, 2005;46;1833-1835.
    Pubmed
  6. Oh, SH, Park, TS, Choi, JR, et al. Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript. Cancer Genet Cytogenet, 2010;200;180-183.
    Pubmed
  7. van Dongen, JJ, Macintyre, EA, Gabert, JA, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 1999;13;1901-1928.
    Pubmed
  8. Kong, XT, Ida, K, Ichikawa, H, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood, 1997;90;1192-1199.
    Pubmed
  9. Mitelman F, Johansson B, Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. Bethesda, MD: National Cancer Institute; [Assessed May 20, 2014]. , at http://cgap.nci.nih.gov/Chromosomes/Mitelman

Article

Letter to the Editor

Blood Res 2015; 50(1): 55-58

Published online March 31, 2015 https://doi.org/10.5045/br.2015.50.1.55

Copyright © The Korean Society of Hematology.

A case of pediatric ALL with t(16;21)(p11.2;q22) and FUS-ERG rearrangement

Mariela C. Coccé1*, Cristina N. Alonso2, Jorge Rossi3, Maria S. Felice2, Myriam R. Gitter2, and Marta S. Gallego1

1Servicio de Genética. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

2Servicio de Hemato-Oncología. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

3Servicio de Inmunología. Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Buenos Aires, Argentina.

Correspondence to: Mariela C. Coccé. Laboratorio de Citogenética, Servicio de Genética, Hospital de Pediatría "Prof. Dr. J. P. Garrahan", Combate de los Pozos 1881, CP 1245, Buenos Aires, Argentina. marielacocce@yahoo.com.ar

Received: July 29, 2014; Revised: September 24, 2014; Accepted: February 12, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    Morphology of leukemic cells at diagnosis showing L1/L2 blasts.

    Blood Research 2015; 50: 55-58https://doi.org/10.5045/br.2015.50.1.55

    Fig 2.

    Figure 2.

    (A) Partial karyotype showing a reciprocal translocation between 16p11.2 and 21q22; (B) Sequencing analysis of the RT-PCR product identifying a fusion between exon 7 of FUS and exon 6 of ERG.

    Blood Research 2015; 50: 55-58https://doi.org/10.5045/br.2015.50.1.55

    References

    1. Huret, JL. t(16;21)(p11;q22). Atlas Genet Cytogenet Oncol Haematol, 2005;9;36-38.
    2. Ichikawa, H, Shimizu, K, Hayashi, Y, Ohki, M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res, 1994;54;2865-2868.
      Pubmed
    3. Liu, F, Gao, L, Jing, Y, et al. Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia. Leuk Lymphoma, 2013;54;1521-1526.
      Pubmed
    4. Heller, A, Loncarevic, IF, Glaser, M, et al. Breakpoint differentiation in chromosomal aberrations of hematological malignancies: Identification of 33 previously unrecorded breakpoints. Int J Oncol, 2004;24;127-136.
      Pubmed
    5. Kanazawa, T, Ogawa, C, Taketani, T, Taki, T, Hayashi, Y, Morikawa, A. TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease. Leuk Lymphoma, 2005;46;1833-1835.
      Pubmed
    6. Oh, SH, Park, TS, Choi, JR, et al. Two childhood cases of acute leukemia with t(16;21)(p11.2;q22): second case report of infantile acute lymphoblastic leukemia with unusual type of FUS-ERG chimeric transcript. Cancer Genet Cytogenet, 2010;200;180-183.
      Pubmed
    7. van Dongen, JJ, Macintyre, EA, Gabert, JA, et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 1999;13;1901-1928.
      Pubmed
    8. Kong, XT, Ida, K, Ichikawa, H, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood, 1997;90;1192-1199.
      Pubmed
    9. Mitelman F, Johansson B, Mertens F. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. Bethesda, MD: National Cancer Institute; [Assessed May 20, 2014]. , at http://cgap.nci.nih.gov/Chromosomes/Mitelman
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