Bone marrow hypoplasia, isochromosome 8q and deletion of chromosome 6q preceding B-cell lymphoma

Nae Yu; Yoonjung Kim; Sung-eun Choi; Juwon Kim; Yu Ri Kim; Jong Rak Choi; Kyung-A Lee

doi:10.5045/br.2014.49.3.200

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Blood Res 2014; 49(3):

Published online September 25, 2014

https://doi.org/10.5045/br.2014.49.3.200

Bone marrow hypoplasia, isochromosome 8q and deletion of chromosome 6q preceding B-cell lymphoma

Nae Yu¹, Yoonjung Kim¹, Sung-eun Choi², Juwon Kim³, Yu Ri Kim⁴, Jong Rak Choi¹, and Kyung-A Lee^1*

Author Info. +

¹Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

³Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to : Kyung-A Lee. Department of Laboratory Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. KAL119@yuhs.ac

Received: April 8, 2014; Revised: May 26, 2014; Accepted: August 22, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article

Letter to the Editor

Blood Res 2014; 49(3): 200-203

Published online September 25, 2014 https://doi.org/10.5045/br.2014.49.3.200

Bone marrow hypoplasia, isochromosome 8q and deletion of chromosome 6q preceding B-cell lymphoma

Nae Yu¹, Yoonjung Kim¹, Sung-eun Choi², Juwon Kim³, Yu Ri Kim⁴, Jong Rak Choi¹, and Kyung-A Lee^1*

¹Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

³Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Kyung-A Lee. Department of Laboratory Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. KAL119@yuhs.ac

Received: April 8, 2014; Revised: May 26, 2014; Accepted: August 22, 2014

Fig 1.

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Figure 1.

Initial bone marrow biopsy showed (A) aplastic marrow (hematoxylin and eosin stain, ×100). In August 2010, repeat biopsy showed (B) increased cellularity with abnormal lymphoid infiltration that was (C) positive for CD20 on immunohistochemical stain (×100).

Blood Research 2014; 49: 200-203https://doi.org/10.5045/br.2014.49.3.200

Fig 2.

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Figure 2.

Giemsa-banded karyotype showing 46,XY,del(6)(q16),i(8)(q10) 9 months before evidence of B-cell lymphoma in the bone marrow. The abnormal chromosomes are marked by arrows.

Blood Research 2014; 49: 200-203https://doi.org/10.5045/br.2014.49.3.200