Original Article
Split Viewer
Blood Res 2013; 48(3):
Published online September 25, 2013
https://doi.org/10.5045/br.2013.48.3.193
© The Korean Society of Hematology
Mean cell volumes of neutrophils and monocytes are promising markers of sepsis in elderly patients
Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine, Daegu, Korea.
Correspondence to : Correspondence to Sang-Gyung Kim, M.D., Ph.D. Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine, 17-33, Duryugonwon-ro, Nam-gu, Daegu 705-718, Korea. Tel: +82-53-650-4145, Fax: +82-53-653-8672, sgkim@cu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background
Sepsis in elderly patients is a major cause of morbidity and mortality in the clinical setting. The aim of this study was to assess the diagnostic significance of volume conductivity scatter (VCS) parameters and to compare their reliability with that of inflammatory markers.
Methods
Patients (N=85) were divided into 3 groups according to their clinical history and culture results: control (N=29), localized infection (N=38), and sepsis (N=18). VCS parameters were obtained using a UniCel DxH 800 Coulter system. Cut-off values were established based on receiver operator characteristic (ROC) curves.
Results
The mean volumes of neutrophils (MNV) and monocytes (MMV) were higher in the sepsis group than in the localized infection and control groups (
Conclusion
MNV and MMV, which can be obtained easily using an automated blood analyzer, may be promising hematologic parameters for distinguishing elderly individuals with and without sepsis and may help clinicians in the diagnosis of sepsis.
Keywords Volume of neutrophils, Volume of monocytes, VCS technology, Procalcitonin, Sepsis
PDF
Standard view
Export citation
Share Article
Original Article
Blood Res 2013; 48(3): 193-197
Published online September 25, 2013 https://doi.org/10.5045/br.2013.48.3.193
Copyright © The Korean Society of Hematology.
Mean cell volumes of neutrophils and monocytes are promising markers of sepsis in elderly patients
A-Jin Lee, and Sang-Gyung Kim*
Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine, Daegu, Korea.
Correspondence to: Correspondence to Sang-Gyung Kim, M.D., Ph.D. Department of Laboratory Medicine, Catholic University of Daegu, School of Medicine, 17-33, Duryugonwon-ro, Nam-gu, Daegu 705-718, Korea. Tel: +82-53-650-4145, Fax: +82-53-653-8672, sgkim@cu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background
Sepsis in elderly patients is a major cause of morbidity and mortality in the clinical setting. The aim of this study was to assess the diagnostic significance of volume conductivity scatter (VCS) parameters and to compare their reliability with that of inflammatory markers.
Methods
Patients (N=85) were divided into 3 groups according to their clinical history and culture results: control (N=29), localized infection (N=38), and sepsis (N=18). VCS parameters were obtained using a UniCel DxH 800 Coulter system. Cut-off values were established based on receiver operator characteristic (ROC) curves.
Results
The mean volumes of neutrophils (MNV) and monocytes (MMV) were higher in the sepsis group than in the localized infection and control groups (
Conclusion
MNV and MMV, which can be obtained easily using an automated blood analyzer, may be promising hematologic parameters for distinguishing elderly individuals with and without sepsis and may help clinicians in the diagnosis of sepsis.
Keywords: Volume of neutrophils, Volume of monocytes, VCS technology, Procalcitonin, Sepsis
Fig 1.
Download
Receiver Operator Characteristic (ROC) curves (with area under the ROC curve) of inflammatory markers (mean neutrophil volume [MNV], mean monocyte volume [MMV], and C-reactive protein [CRP]) and procalcitonin.
-
Table 1 . Characteristics, parameters of infection and inflammation, and VCS parameters..
a)
P value<0.05 (ANOVA with post hoc analysis) was considered statistically significant..Abbreviations: CRP, C-reactive protein; VCS, volume conductivity scatter; MALS, median angle light scatter; UMALS, upper median angle light scatter; LMALS, lower median angle light scatter; LALS, low angle light scatter..
-
Table 2 . Sensitivity and specificity at the designated cut-off values of inflammatory markers for predicting sepsis..
Abbreviations: MNV, mean cell volume of neutrophils; MMV, mean cell volume of monocytes; CRP, C-reactive protein..
Previous Article
Article Tools
Stats or Metrics
Share this article on
Related articles in BR
-
Elevated levels of activated and inactivated thrombin-activatable fibrinolysis inhibitor in patients with sepsis
Rojin Park, Jaewoo Song, and Seong Soo A. An
Korean J Hematol 2010; 45(4): 264-268 -
A Case of Massive Intravascular Hemolysis Associated with Clostiridium perfringens Sepsis
Kyung Sun Park, So Young Kang, Woo In Lee
Korean J Hematol 2007; 42(4): 409-413
