Characterization of antiphospholipid antibodies in chronic hepatitis B infection

Ji Young Huh; Dae Young Yi; Seong Gyu Hwang; Jin Jung Choi; Myung Seo Kang

doi:10.5045/kjh.2011.46.1.36

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Original Article

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Korean J Hematol 2011; 46(1):

Published online March 31, 2011

https://doi.org/10.5045/kjh.2011.46.1.36

Characterization of antiphospholipid antibodies in chronic hepatitis B infection

Ji Young Huh^1*, Dae Young Yi¹, Seong Gyu Hwang², Jin Jung Choi², and Myung Seo Kang³

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¹Department of Laboratory Medicine, CHA Bundang Medical Center, Seongnam, Korea.

²Department of Internal Medicine, CHA Bundang Medical Center, Seongnam, Korea.

³Department of Laboratory Medicine, CHA Kangnam Medical Center, Seoul, Korea.

Correspondence to : Correspondence to Ji Young Huh, M.D., Ph.D. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Sungnam 463-712, Korea. Tel: +82-31-780-5451, Fax: +82-31-780-5476, jiyoungh@cha.ac.kr

Received: November 5, 2010; Revised: February 13, 2011; Accepted: February 15, 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Background

Many infections are associated with antiphospholipid antibodies (aPLs). The purpose of this study was to investigate the prevalence, persistence, clinical significance, and characteristics of aPLs in hepatitis B virus (HBV)-infected patients.

Methods

This study included 143 patients with HBV infection and 32 healthy individuals as controls. The presence of anticardiolipin antibodies (aCL Ab), anti-β₂-glycoprotein I antibodies (β₂GPI Ab), and lupus anticoagulant (LA) was assessed.

Results

The total prevalence of aPLs in HBV-infected patients was 12.6% (18 of 143). Of these 18 patients, 15 had low to medium titers of aCL Ab (10 with IgM, 4 with IgG, and 1 with both isotypes). β₂GPI Ab and LA were detected in 3 (2.1%) and 2 (1.4%) patients with HBV infection, respectively. In follow-up specimens from 14 patients with elevated levels of aCL Ab or β₂GPI Ab, 10 (71.4%) showed the persistent presence of aPLs. No clinical manifestations related to aPLs were identified.

Conclusion

In HBV-infected patients, the most frequently detected antiphospholipid antibodies were IgM aCL Ab, which have a weak association with the clinical manifestations of APS. Unlike the transient presence reported for other infection-associated aPLs, most aPLs were persistently detected over a 12-week period in patients with HBV infection.

Keywords Anticardiolipin antibodies, Anti-β₂-glycoprotein I antibodies, Lupus coagulation inhibitor, Hepatitis B virus

Article

Original Article

Korean J Hematol 2011; 46(1): 36-40

Published online March 31, 2011 https://doi.org/10.5045/kjh.2011.46.1.36

Characterization of antiphospholipid antibodies in chronic hepatitis B infection

Ji Young Huh^1*, Dae Young Yi¹, Seong Gyu Hwang², Jin Jung Choi², and Myung Seo Kang³

¹Department of Laboratory Medicine, CHA Bundang Medical Center, Seongnam, Korea.

²Department of Internal Medicine, CHA Bundang Medical Center, Seongnam, Korea.

³Department of Laboratory Medicine, CHA Kangnam Medical Center, Seoul, Korea.

Correspondence to: Correspondence to Ji Young Huh, M.D., Ph.D. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Yatap-dong, Bundang-gu, Sungnam 463-712, Korea. Tel: +82-31-780-5451, Fax: +82-31-780-5476, jiyoungh@cha.ac.kr

Received: November 5, 2010; Revised: February 13, 2011; Accepted: February 15, 2011

Abstract

Background

Methods

Results

Conclusion

Keywords: Anticardiolipin antibodies, Anti-β₂-glycoprotein I antibodies, Lupus coagulation inhibitor, Hepatitis B virus

Abstract

Fig 1.

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Figure 1.

Distribution of anticardiolipin antibody titers in hepatitis B virus (HBV)-infected patients and normal controls, IgM isotype (A) and IgG isotype (B).

Blood Research 2011; 46: 36-40https://doi.org/10.5045/kjh.2011.46.1.36

Table 1 . Prevalence of antiphospholipid antibodies (aCL Ab, β₂GPI Ab, and lupus anticoagulant) in HBV-infected patients..

Abbreviations: HBV, hepatitis B virus; aCL Ab, anticardiolipin antibodies; β₂GPI Ab, anti-β₂-glycoprotein I antibodies..

Table 2 . Characteristics of HBV-infected patients with antiphospholipid antibodies and the types of antiphospholipid antibodies..

^a)Patients were divided into 2 groups on the basis of the hepatitis B e antigen and antibody status and the HBV DNA level: chronic hepatitis B patients and patients with inactive HBsAg carrier state..

Abbreviations: HBV, hepatitis B virus; M, male; F, female; aCL, anticardiolipin antibodies; β₂GPI, anti-β₂-glycoprotein I antibodies; LA, lupus anticoagulant..

Table 3 . Follow-up duration and results of aCL Ab and β₂GPI Ab testing in antiphospholipid antibody-positive HBV-infected patients..

^a)Follow-up specimens of 3 patients (134, 140, and 153) could not be obtained..

Abbreviations: HBV, hepatitis B virus; aCL Ab, anticardiolipin antibodies; β₂GPI Ab, anti-2-glycoprotein I antibodies; MPL, IgM phospholipid unit; GPL, IgG phospholipid unit; SMU, standard IgM unit; SGU, standard IgG unit;-, negative; NT, not tested..