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Blood Res 2014; 49(2):

Published online June 25, 2014

https://doi.org/10.5045/br.2014.49.2.134

© The Korean Society of Hematology

Simultaneous presentation of JAK2 V617F mutation-related essential thrombocythemia and B-cell chronic lymphocytic leukemia

Guido D'Angelo1*, Anna Maria Hotz2, Fabrizio Ciambelli3, and Sergio Pauli3

Author Info. +

1Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

2Anatomia Patologica, Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

3Oncologia - Ematologia, Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

Correspondence to : Guido D'Angelo. Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Via Pastori 4, 21013 - Gallarate, Varese, Italy. guido.dangelo@aogallarate.it

Received: February 6, 2014; Revised: March 3, 2014; Accepted: May 15, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

FIGURES

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Fig. 1.

(A) Bone marrow aspirate (May-Grünwald-Giemsa, MGG) showing lymphoid hyperplasia represented by small cells with scant cytoplasm (magnification 400×); (B) Bone marrow biopsy (hematoxylin-eosin) showing lymphoid hyperplasia and simultaneous megakaryocytic hyperplasia, isolated and in groups (magnification 200×); (C) Bone marrow biopsy showing a population of small lymphoid cells that were CD5+ (magnification 200×); and (D) Bone marrow aspirate (MGG) showing large megakaryocyte with hyperlobated nucleus (magnification 1,000×).


Fig. 2.

Pathogenetic hypothesis of the simultaneous presence of myeloid and lymphoid disease. Abbreviation: EPMH-SC, early progenitor multipotential hematopoietic stem cell.


REFERENCES

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  1. Bethard, WF, Block, MH, Robson, M. Coexistent chronic lymphatic leukemia and polycythemia vera; morphologic and clinical studies with particular reference to unusual iron metabolism. Blood, 1953;8;934-943.
    Pubmed
  2. George, TI, Horny, HP. Systemic mastocytosis. Hematol Oncol Clin North Am, 2011;25;Array-1083.
    Pubmed
  3. Marti, GE, Rawstron, AC, Ghia, P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol, 2005;130;325-332.
    Pubmed
  4. Tefferi, A. Polycythemia vera and essential thrombocythemia: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol, 2013;88;507-516.
    Pubmed
  5. Hauck, G, Jonigk, D, Kreipe, H, Hussein, K. Simultaneous and sequential concurrent myeloproliferative and lymphoproliferative neoplasms. Acta Haematol, 2013;129;187-196.
    Pubmed
  6. Chintapatla, R, Battini, R, Wiernik, PH. Chronic lymphocytic leukemia with essential thrombocythemia: asbestos exposure association?. Clin Adv Hematol Oncol, 2012;10;752-755.
    Pubmed
  7. Tabaczewski, P, Nadesan, S, Lim, SH. Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell?. Leuk Res, 2009;33;854-855.
    Pubmed
  8. Gaillard, JB, Carillo, S, Henry, L, Jourdan, E, Lavabre-Bertrand, T. Association of myeloproliferative and lymphoproliferative disorders. Clin Adv Hematol Oncol, 2012;10;756-757.
    Pubmed
  9. Vannucchi, AM, Masala, G, Antonioli, E, et al. Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms. Cancer Epidemiol Biomarkers Prev, 2009;18;2068-2073.
    Pubmed
  10. Mullighan, CG, Zhang, J, Harvey, RC, et al. JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A, 2009;106;9414-9418.
    Pubmed
  11. Orozco, CA, Acevedo, A, Cortina, L, et al. The combined expression patterns of Ikaros isoforms characterize different hematological tumor subtypes. PLoS One, 2013;8;e82411.
    Pubmed
  12. Henry, L, Carillo, S, Jourdan, E, Arnaud, A, Brun, S, Lavabre-Bertrand, T. Association of essential thrombocythemia and chronic lymphocytic leukemia: absence of the V617F JAK2 mutation in the lymphoid compartment. Am J Hematol, 2007;82;500-501.
    Pubmed

Article

Letter to the Editor

Blood Res 2014; 49(2): 134-137

Published online June 25, 2014 https://doi.org/10.5045/br.2014.49.2.134

Copyright © The Korean Society of Hematology.

Simultaneous presentation of JAK2 V617F mutation-related essential thrombocythemia and B-cell chronic lymphocytic leukemia

Guido D'Angelo1*, Anna Maria Hotz2, Fabrizio Ciambelli3, and Sergio Pauli3

1Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

2Anatomia Patologica, Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

3Oncologia - Ematologia, Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Italy.

Correspondence to: Guido D'Angelo. Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" - Gallarate, Via Pastori 4, 21013 - Gallarate, Varese, Italy. guido.dangelo@aogallarate.it

Received: February 6, 2014; Revised: March 3, 2014; Accepted: May 15, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Download
    Figure 1.

    (A) Bone marrow aspirate (May-Grünwald-Giemsa, MGG) showing lymphoid hyperplasia represented by small cells with scant cytoplasm (magnification 400×); (B) Bone marrow biopsy (hematoxylin-eosin) showing lymphoid hyperplasia and simultaneous megakaryocytic hyperplasia, isolated and in groups (magnification 200×); (C) Bone marrow biopsy showing a population of small lymphoid cells that were CD5+ (magnification 200×); and (D) Bone marrow aspirate (MGG) showing large megakaryocyte with hyperlobated nucleus (magnification 1,000×).

    Blood Research 2014; 49: 134-137https://doi.org/10.5045/br.2014.49.2.134

    Fig 2.

    Download
    Figure 2.

    Pathogenetic hypothesis of the simultaneous presence of myeloid and lymphoid disease. Abbreviation: EPMH-SC, early progenitor multipotential hematopoietic stem cell.

    Blood Research 2014; 49: 134-137https://doi.org/10.5045/br.2014.49.2.134

    References

    1. Bethard, WF, Block, MH, Robson, M. Coexistent chronic lymphatic leukemia and polycythemia vera; morphologic and clinical studies with particular reference to unusual iron metabolism. Blood, 1953;8;934-943.
      Pubmed
    2. George, TI, Horny, HP. Systemic mastocytosis. Hematol Oncol Clin North Am, 2011;25;Array-1083.
      Pubmed
    3. Marti, GE, Rawstron, AC, Ghia, P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol, 2005;130;325-332.
      Pubmed
    4. Tefferi, A. Polycythemia vera and essential thrombocythemia: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol, 2013;88;507-516.
      Pubmed
    5. Hauck, G, Jonigk, D, Kreipe, H, Hussein, K. Simultaneous and sequential concurrent myeloproliferative and lymphoproliferative neoplasms. Acta Haematol, 2013;129;187-196.
      Pubmed
    6. Chintapatla, R, Battini, R, Wiernik, PH. Chronic lymphocytic leukemia with essential thrombocythemia: asbestos exposure association?. Clin Adv Hematol Oncol, 2012;10;752-755.
      Pubmed
    7. Tabaczewski, P, Nadesan, S, Lim, SH. Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell?. Leuk Res, 2009;33;854-855.
      Pubmed
    8. Gaillard, JB, Carillo, S, Henry, L, Jourdan, E, Lavabre-Bertrand, T. Association of myeloproliferative and lymphoproliferative disorders. Clin Adv Hematol Oncol, 2012;10;756-757.
      Pubmed
    9. Vannucchi, AM, Masala, G, Antonioli, E, et al. Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms. Cancer Epidemiol Biomarkers Prev, 2009;18;2068-2073.
      Pubmed
    10. Mullighan, CG, Zhang, J, Harvey, RC, et al. JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A, 2009;106;9414-9418.
      Pubmed
    11. Orozco, CA, Acevedo, A, Cortina, L, et al. The combined expression patterns of Ikaros isoforms characterize different hematological tumor subtypes. PLoS One, 2013;8;e82411.
      Pubmed
    12. Henry, L, Carillo, S, Jourdan, E, Arnaud, A, Brun, S, Lavabre-Bertrand, T. Association of essential thrombocythemia and chronic lymphocytic leukemia: absence of the V617F JAK2 mutation in the lymphoid compartment. Am J Hematol, 2007;82;500-501.
      Pubmed
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