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Blood Res 2013; 48(4):

Published online December 31, 2013

https://doi.org/10.5045/br.2013.48.4.300

© The Korean Society of Hematology

Lymphoplasmacytic non-Hodgkin lymphoma/Waldenström's macroglobulinemia with CD5+, CD23+, and CD10-

Guido D'Angelo1*, Anna Maria Hotz2, and Marta Monti1

Author Info. +

1Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Varese, Italy.

2Anatomia Patologica, Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Varese, Italy.

Correspondence to : Guido D'Angelo. Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Via Pastori 4, Varese, Italy. guido.dangelo@aogallarate.it

Received: October 14, 2013; Revised: November 22, 2013; Accepted: November 28, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

FIGURES

Go to
Fig. 1.

Bone marrow aspirate. Lymphocytes with lymphoplasmacytoid appearance (arrows).


Fig. 2.

(A) Bone marrow flow cytometry finding of CD5+ lymphoplasmacytic lymphoma/WM. (B) Immunohistochemistry of bone marrow biopsy showing CD5+.


Fig. 3.

(A) Bone marrow flow cytometry finding of CD23+ lymphoplasmacytic lymphoma/WM. (B) Immunohistochemistry of bone marrow biopsy showing CD23+.


TABLES

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Table. 1.

Table 1 Diagnostic criteria for Wladenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.


REFERENCES

Go to
  1. Waldenstrom, J. Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia: a new syndrome?. Acta Med Scand, 1944;117;216-247.
  2. Owen, RG, Treon, SP, Al-Katib, A, et al. Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol, 2003;30;110-115.
    Pubmed
  3. Tournilhac, O, Santos, DD, Xu, L, et al. Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol, 2006;17;1275-1282.
    Pubmed
  4. Mansoor, A, Medeiros, LJ, Weber, DM, et al. Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course. Am J Clin Pathol, 2001;116;543-549.
    Pubmed
  5. Treon, SP, Hunter, ZR. A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood, 2013;121;4434-4436.
    Pubmed
  6. Pangalis, GA, Kyrtsonis, MC, Kontopidou, FN, et al. Differential diagnosis of Waldenstrom's macroglobulinemia from other low-grade B-cell lymphoproliferative disorders. Semin Oncol, 2003;30;201-205.
    Pubmed
  7. Naderi, N, Yang, DT. Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia. Arch Pathol Lab Med, 2013;137;580-585.
    Pubmed
  8. Konoplev, S, Medeiros, LJ, Bueso-Ramos, CE, Jorgensen, JL, Lin, P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia. Am J Clin Pathol, 2005;124;414-420.
    Pubmed
  9. Owen, RG, Barrans, SL, Richards, SJ, et al. Waldenstrom macroglobulinemia. Development of diagnostic criteria and identification of prognostic factors. Am J Clin Pathol, 2001;116;420-428.
    Pubmed
  10. Morice, WG, Chen, D, Kurtin, PJ, Hanson, CA, McPhail, ED. Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenstrom's macroglobulinemia. Mod Pathol, 2009;22;807-816.
    Pubmed
  11. Hunter, ZR, Branagan, AR, Manning, R, et al. CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia. Clin Lymphoma, 2005;5;246-249.
    Pubmed
  12. San Miguel, JF, Vidriales, MB, Ocio, E, et al. Immunophenotypic analysis of Waldenstrom's macroglobulinemia. Semin Oncol, 2003;30;187-195.
    Pubmed
  13. Owen, RG, Hillmen, P, Rawstron, AC. CD52 expression in Waldenstrom's macroglobulinemia: implications for alemtuzumab therapy and response assessment. Clin Lymphoma, 2005;5;278-281.
    Pubmed

Article

Letter to the Editor

Blood Res 2013; 48(4): 300-303

Published online December 31, 2013 https://doi.org/10.5045/br.2013.48.4.300

Copyright © The Korean Society of Hematology.

Lymphoplasmacytic non-Hodgkin lymphoma/Waldenström's macroglobulinemia with CD5+, CD23+, and CD10-

Guido D'Angelo1*, Anna Maria Hotz2, and Marta Monti1

1Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Varese, Italy.

2Anatomia Patologica, Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Varese, Italy.

Correspondence to: Guido D'Angelo. Laboratorio di Chimica-Clinica, Ematologia e Microbiologia (Ematologia/Coagulazione), Azienda Ospedaliera "S. Antonio Abate" di Gallarate, Via Pastori 4, Varese, Italy. guido.dangelo@aogallarate.it

Received: October 14, 2013; Revised: November 22, 2013; Accepted: November 28, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

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    Figure 1.

    Bone marrow aspirate. Lymphocytes with lymphoplasmacytoid appearance (arrows).

    Blood Research 2013; 48: 300-303https://doi.org/10.5045/br.2013.48.4.300

    Fig 2.

    Download
    Figure 2.

    (A) Bone marrow flow cytometry finding of CD5+ lymphoplasmacytic lymphoma/WM. (B) Immunohistochemistry of bone marrow biopsy showing CD5+.

    Blood Research 2013; 48: 300-303https://doi.org/10.5045/br.2013.48.4.300

    Fig 3.

    Download
    Figure 3.

    (A) Bone marrow flow cytometry finding of CD23+ lymphoplasmacytic lymphoma/WM. (B) Immunohistochemistry of bone marrow biopsy showing CD23+.

    Blood Research 2013; 48: 300-303https://doi.org/10.5045/br.2013.48.4.300

    Table 1 . Diagnostic criteria for Wladenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance..


    References

    1. Waldenstrom, J. Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia: a new syndrome?. Acta Med Scand, 1944;117;216-247.
    2. Owen, RG, Treon, SP, Al-Katib, A, et al. Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol, 2003;30;110-115.
      Pubmed
    3. Tournilhac, O, Santos, DD, Xu, L, et al. Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol, 2006;17;1275-1282.
      Pubmed
    4. Mansoor, A, Medeiros, LJ, Weber, DM, et al. Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course. Am J Clin Pathol, 2001;116;543-549.
      Pubmed
    5. Treon, SP, Hunter, ZR. A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood, 2013;121;4434-4436.
      Pubmed
    6. Pangalis, GA, Kyrtsonis, MC, Kontopidou, FN, et al. Differential diagnosis of Waldenstrom's macroglobulinemia from other low-grade B-cell lymphoproliferative disorders. Semin Oncol, 2003;30;201-205.
      Pubmed
    7. Naderi, N, Yang, DT. Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia. Arch Pathol Lab Med, 2013;137;580-585.
      Pubmed
    8. Konoplev, S, Medeiros, LJ, Bueso-Ramos, CE, Jorgensen, JL, Lin, P. Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia. Am J Clin Pathol, 2005;124;414-420.
      Pubmed
    9. Owen, RG, Barrans, SL, Richards, SJ, et al. Waldenstrom macroglobulinemia. Development of diagnostic criteria and identification of prognostic factors. Am J Clin Pathol, 2001;116;420-428.
      Pubmed
    10. Morice, WG, Chen, D, Kurtin, PJ, Hanson, CA, McPhail, ED. Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma and correlation with Waldenstrom's macroglobulinemia. Mod Pathol, 2009;22;807-816.
      Pubmed
    11. Hunter, ZR, Branagan, AR, Manning, R, et al. CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia. Clin Lymphoma, 2005;5;246-249.
      Pubmed
    12. San Miguel, JF, Vidriales, MB, Ocio, E, et al. Immunophenotypic analysis of Waldenstrom's macroglobulinemia. Semin Oncol, 2003;30;187-195.
      Pubmed
    13. Owen, RG, Hillmen, P, Rawstron, AC. CD52 expression in Waldenstrom's macroglobulinemia: implications for alemtuzumab therapy and response assessment. Clin Lymphoma, 2005;5;278-281.
      Pubmed
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