A case of oxaliplatin-induced immune-mediated thrombocytopenia

Seong Eun Suh; Moon Ju Jang; So Young Chong; Richard H. Aster; Brian R. Curtis; Doyeun Oh

doi:10.5045/br.2014.49.1.61

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Case Report

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Blood Res 2014; 49(1):

Published online March 31, 2014

https://doi.org/10.5045/br.2014.49.1.61

A case of oxaliplatin-induced immune-mediated thrombocytopenia

Seong Eun Suh¹, Moon Ju Jang¹, So Young Chong¹, Richard H. Aster², Brian R. Curtis², and Doyeun Oh^1*

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¹Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.

²Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, WI, USA.

Correspondence to : Correspondence to Doyeun Oh, M.D. Department of Internal Medicine, CHA University, Bundang CHA Medical Center, 59, Yatap-ro, Bundang-gu, Seongnam 463-712, Korea. Tel: +82-31-780-5217, Fax: +82-31-780-5219, doh@cha.ac.kr

Received: July 18, 2012; Revised: August 18, 2012; Accepted: January 9, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Abstract

Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.

Keywords Oxaliplatin, Thrombocytopenia, Immune, Drug-dependent platelet antibody

Article

Case Report

Blood Res 2014; 49(1): 61-64

Published online March 31, 2014 https://doi.org/10.5045/br.2014.49.1.61

A case of oxaliplatin-induced immune-mediated thrombocytopenia

Seong Eun Suh¹, Moon Ju Jang¹, So Young Chong¹, Richard H. Aster², Brian R. Curtis², and Doyeun Oh^1*

¹Department of Internal Medicine, School of Medicine, CHA University, Seongnam, Korea.

²Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin, Milwaukee, WI, USA.

Correspondence to:Correspondence to Doyeun Oh, M.D. Department of Internal Medicine, CHA University, Bundang CHA Medical Center, 59, Yatap-ro, Bundang-gu, Seongnam 463-712, Korea. Tel: +82-31-780-5217, Fax: +82-31-780-5219, doh@cha.ac.kr

Received: July 18, 2012; Revised: August 18, 2012; Accepted: January 9, 2014

Abstract

Keywords: Oxaliplatin, Thrombocytopenia, Immune, Drug-dependent platelet antibody

Abstract

Fig 1.

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Figure 1.

Clinical course of the patient.

Blood Research 2014; 49: 61-64https://doi.org/10.5045/br.2014.49.1.61

Fig 2.

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Figure 2.

Detection of oxaliplatin-dependent platelet antibodies by using flow cytometry. Patient's serum, but not normal serum, reacted with group O platelets in the presence of oxaliplatin 0.1 mg/mL (black histograms) but not in its absence (gray). No reactions were obtained with fluorouracil (5-FU) or leucovorin (not shown). Numbers shown above for each histogram represent the median fluorescence intensity (MFI) values, in log scale.

Blood Research 2014; 49: 61-64https://doi.org/10.5045/br.2014.49.1.61