Letter to the Editor

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Blood Res 2015; 50(3):

Published online September 22, 2015

https://doi.org/10.5045/br.2015.50.3.184

© The Korean Society of Hematology

Unusual association of CD8+ T-cell lymphocytosis with invasive thymoma

Hee Jin Huh1*, Jae-Woo Chung1, Hyun Jung Lee2, and Seok Lae Chae1

1Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

2Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Correspondence to : Hee Jin Huh. Department of Laboratory Medicine, Dongguk University Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, Goyang 10326, Korea. hjhuh@dumc.or.kr

Received: December 29, 2014; Revised: January 13, 2015; Accepted: July 27, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fig. 1.

(A) Peripheral blood smear showing mature lymphocytes with dense chromatin, no nucleoli, and scanty agranular cytoplasm (Wright-Giemsa stain, ×1,000). (B) Bone marrow lymphocytosis on aspirate (Wright-Giemsa stain, ×1,000).


Fig. 2.

Change of white blood cell and lymphocyte counts during the follow-up period.


  1. Morgenthaler, TI, Brown, LR, Colby, TV, Harper, CM, Coles, DT. Thymoma. Mayo Clin Proc, 1993;68;1110-1123.
    Pubmed
  2. Barton, AD. T-cell lymphocytosis associated with lymphocyte-rich thymoma. Cancer, 1997;80;1409-1417.
    Pubmed
  3. Bauduer, F, Archambaud, F, Mazères, F, Ellie, E, Ducout, L. T-cell lymphocytosis associated with thymoma and myasthenia. Rev Med Interne, 2002;23;951-952.
    Pubmed
  4. Morales, M, Trujillo, M, del Carmen Maeso, M, Piris, MA. Thymoma and progressive T-cell lymphocytosis. Ann Oncol, 2007;18;603-604.
    Pubmed
  5. Puljiz, Z, Karin, Z, Bratanic, A, et al. Late distant metastases of malignant thymoma associated with peripheral T-cell lymphocytosis. Pathol Int, 2013;63;516-518.
    Pubmed
  6. Chen, HK, Huang, WT, Eng, HL, Lu, HI, Huang, HY. Ossifying thymoma clinically presenting with peripheral T-cell lymphocytosis. Ann Thorac Surg, 2009;88;e5-e7.
    Pubmed
  7. Pedraza, MA. Thymoma immunological and ultrastructural characterization. Cancer, 1977;39;1455-1461.
    Pubmed
  8. Medeiros, LJ, Bhagat, SK, Naylor, P, Fowler, D, Jaffe, ES, Stetler-Stevenson, M. Malignant thymoma associated with T-cell lymphocytosis. A case report with immunophenotypic and gene rearrangement analysis. Arch Pathol Lab Med, 1993;117;279-283.
    Pubmed
  9. Hoffacker, V, Schultz, A, Tiesinga, JJ, et al. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood, 2000;96;3872-3879.
    Pubmed

Article

Letter to the Editor

Blood Res 2015; 50(3): 184-185

Published online September 22, 2015 https://doi.org/10.5045/br.2015.50.3.184

Copyright © The Korean Society of Hematology.

Unusual association of CD8+ T-cell lymphocytosis with invasive thymoma

Hee Jin Huh1*, Jae-Woo Chung1, Hyun Jung Lee2, and Seok Lae Chae1

1Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

2Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

Correspondence to: Hee Jin Huh. Department of Laboratory Medicine, Dongguk University Ilsan Hospital, 27, Dongguk-ro, Ilsandong-gu, Goyang 10326, Korea. hjhuh@dumc.or.kr

Received: December 29, 2014; Revised: January 13, 2015; Accepted: July 27, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Fig 1.

    Figure 1.

    (A) Peripheral blood smear showing mature lymphocytes with dense chromatin, no nucleoli, and scanty agranular cytoplasm (Wright-Giemsa stain, ×1,000). (B) Bone marrow lymphocytosis on aspirate (Wright-Giemsa stain, ×1,000).

    Blood Research 2015; 50: 184-185https://doi.org/10.5045/br.2015.50.3.184

    Fig 2.

    Figure 2.

    Change of white blood cell and lymphocyte counts during the follow-up period.

    Blood Research 2015; 50: 184-185https://doi.org/10.5045/br.2015.50.3.184

    References

    1. Morgenthaler, TI, Brown, LR, Colby, TV, Harper, CM, Coles, DT. Thymoma. Mayo Clin Proc, 1993;68;1110-1123.
      Pubmed
    2. Barton, AD. T-cell lymphocytosis associated with lymphocyte-rich thymoma. Cancer, 1997;80;1409-1417.
      Pubmed
    3. Bauduer, F, Archambaud, F, Mazères, F, Ellie, E, Ducout, L. T-cell lymphocytosis associated with thymoma and myasthenia. Rev Med Interne, 2002;23;951-952.
      Pubmed
    4. Morales, M, Trujillo, M, del Carmen Maeso, M, Piris, MA. Thymoma and progressive T-cell lymphocytosis. Ann Oncol, 2007;18;603-604.
      Pubmed
    5. Puljiz, Z, Karin, Z, Bratanic, A, et al. Late distant metastases of malignant thymoma associated with peripheral T-cell lymphocytosis. Pathol Int, 2013;63;516-518.
      Pubmed
    6. Chen, HK, Huang, WT, Eng, HL, Lu, HI, Huang, HY. Ossifying thymoma clinically presenting with peripheral T-cell lymphocytosis. Ann Thorac Surg, 2009;88;e5-e7.
      Pubmed
    7. Pedraza, MA. Thymoma immunological and ultrastructural characterization. Cancer, 1977;39;1455-1461.
      Pubmed
    8. Medeiros, LJ, Bhagat, SK, Naylor, P, Fowler, D, Jaffe, ES, Stetler-Stevenson, M. Malignant thymoma associated with T-cell lymphocytosis. A case report with immunophenotypic and gene rearrangement analysis. Arch Pathol Lab Med, 1993;117;279-283.
      Pubmed
    9. Hoffacker, V, Schultz, A, Tiesinga, JJ, et al. Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood, 2000;96;3872-3879.
      Pubmed
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