Korean J Hematol 2002; 37(2):
Published online June 30, 2002
© The Korean Society of Hematology
아밀라제를 생성하는 IgG Kappa형 다발성골수종 1례
김경천, 이홍석, 장용석, 이원식, 송홍석
한동대학교부속 선린병원 내과,
계명대학교 의과대학 내과학교실,
계명대학교 의과대학 유전의학연구소
Amylase-Producing IgG Kappa Type Multiple Myeloma
Amylase-producing multiple myeloma is a rare disorder and has poor prognosis. Its characteristics are elevation of salivary type amylase, extensive extramedullary spread, extensive bone destruction, shorter survival time, and abnormal karyotype. Recently, we have experienced a case of amylase-producing IgG kappa type multiple myeloma in a 63-year-old woman. On admission, serum and urine amylase was 8,450U/L and 169,710U/L, 85% and 86% of which was determined to be the salivary type, respectively. The other cause of hyperamylasemia had not been detected. The presence of immunoglobulin and amylase in the myeloma cells was demonstrated immunohistochemically. Bone marrow aspiration smear revealed 59.1% plasma cells. The
cytogenetic study of bone marrow cell showed normal karyotype. The patient died 3 months after chemotherapy with melphalan and prednisolone.
Keywords Hyperamylasemia; Multiple myeloma; Chemotherapy;
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Korean J Hematol 2002; 37(2): 158-160
Published online June 30, 2002
Copyright © The Korean Society of Hematology.
아밀라제를 생성하는 IgG Kappa형 다발성골수종 1례
김경천, 이홍석, 장용석, 이원식, 송홍석
한동대학교부속 선린병원 내과,
계명대학교 의과대학 내과학교실,
계명대학교 의과대학 유전의학연구소
Amylase-Producing IgG Kappa Type Multiple Myeloma
Kyoung Cheon Kim, Hong Seok Lee, Yong Seok Jang, Won Sik Lee, Hong Suk Song
Department of Internal Medicine, Sunlin Hospital, Handong University, Pohang, Korea
Department of Internal Medicine, Institute of Medical Cytogentics and Dongsan Medical Center, Keimyung University, School of Medicine, Taegu, Korea
Abstract
Amylase-producing multiple myeloma is a rare disorder and has poor prognosis. Its characteristics are elevation of salivary type amylase, extensive extramedullary spread, extensive bone destruction, shorter survival time, and abnormal karyotype. Recently, we have experienced a case of amylase-producing IgG kappa type multiple myeloma in a 63-year-old woman. On admission, serum and urine amylase was 8,450U/L and 169,710U/L, 85% and 86% of which was determined to be the salivary type, respectively. The other cause of hyperamylasemia had not been detected. The presence of immunoglobulin and amylase in the myeloma cells was demonstrated immunohistochemically. Bone marrow aspiration smear revealed 59.1% plasma cells. The
cytogenetic study of bone marrow cell showed normal karyotype. The patient died 3 months after chemotherapy with melphalan and prednisolone.
Keywords: Hyperamylasemia, Multiple myeloma, Chemotherapy,
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