Case Report
Korean J Hematol 2006; 41(4):
Published online December 30, 2006
https://doi.org/10.5045/kjh.2006.41.4.317
© The Korean Society of Hematology
골수형성이상증후군에 동반된 자가면역용혈빈혈
심광연, 노미오, 김현정, 배상병, 김찬규, 이규택, 이유경, 박성규, 원종호, 박희숙, 홍대식
순천향대학교 의과대학, 내과학교실, 진단검사의학교실
Autoimmune Hemolytic Anemia in Myelodysplastic Syndrome
Autoimmune paraneoplastic syndromes are encountered in patients with myelodysplastic syndromes. A review of case reports suggested 10% of myelodysplastic syndrome patients may experience various autoimmune syndromes, associated with immunological-mediated hematologic abnormalities, such as Coombs' negative hemolytic anemia. In patients with myelodysplastic syndrome, Coombs' negative hemolytic anemia may be underdiagnosed due to its association with reticulocytopenia. Therefore, the findings from a peripheral blood smear and measurement of haptoglobin level are important. Autoimmune manifestations respond to immunosuppressive agents, including steroids. Herein, a case with Coombs' negative hemolytic anemia, diagnosed with myelodysplastic syndrome from a bone marrow biopsy, is reported, with a review of the previously reported literature.
Keywords Myelodysplastic syndrome, Autoimmune, Hemolytic anemia
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Case Report
Korean J Hematol 2006; 41(4): 317-320
Published online December 30, 2006 https://doi.org/10.5045/kjh.2006.41.4.317
Copyright © The Korean Society of Hematology.
골수형성이상증후군에 동반된 자가면역용혈빈혈
심광연, 노미오, 김현정, 배상병, 김찬규, 이규택, 이유경, 박성규, 원종호, 박희숙, 홍대식
순천향대학교 의과대학, 내과학교실, 진단검사의학교실
Autoimmune Hemolytic Anemia in Myelodysplastic Syndrome
Kwang Yeon Shim, Mi Oh Roh, Hyun Jung Kim, Sang Byung Bae, Chan Kyu Kim, Kyu Taeg Lee, You Kyoung Lee, Sung Kyu Park, Jong Ho Won, Hee Sook Park, Dae Sik Hong
Departments of, Internal Medicine, Laboratory Mdedicine, College of Medicine, Soonchunhyang University, Bucheon, Korea
Abstract
Autoimmune paraneoplastic syndromes are encountered in patients with myelodysplastic syndromes. A review of case reports suggested 10% of myelodysplastic syndrome patients may experience various autoimmune syndromes, associated with immunological-mediated hematologic abnormalities, such as Coombs' negative hemolytic anemia. In patients with myelodysplastic syndrome, Coombs' negative hemolytic anemia may be underdiagnosed due to its association with reticulocytopenia. Therefore, the findings from a peripheral blood smear and measurement of haptoglobin level are important. Autoimmune manifestations respond to immunosuppressive agents, including steroids. Herein, a case with Coombs' negative hemolytic anemia, diagnosed with myelodysplastic syndrome from a bone marrow biopsy, is reported, with a review of the previously reported literature.
Keywords: Myelodysplastic syndrome, Autoimmune, Hemolytic anemia
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