Case Report
Korean J Hematol 2006; 41(2):
Published online June 30, 2006
https://doi.org/10.5045/kjh.2006.41.2.129
© The Korean Society of Hematology
TCL1 유전자 과발현을 보인 CD56 양성 T-세포 전림프구성 백혈병: 증례 및 문헌고찰
윤형기, 신명근, 김형준, 김혜란, 박지영, 조덕, 기승정, 김영휴, 신종희, 서순팔, 양동욱
전남대학교 의과대학 진단검사의학교실 및 화순전남대학교병원 진단검사의학과, 조혈계질환 유전체연구센터, 순천성가롤로병원 진단검사의학과
CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature
T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis and an aggressive clinical course. We report here on a case of CD56+ T-PLL that was diagnosed by hematological examination, immunophenotyping and molecular studies including determining the TCL1 expression by using reverse-transcriptase polymerase chain reaction (RT-PCR), and direct sequencing of the RT-PCR product.
Keywords T-cell Prolymphocytic Leukemia, TCL1, CD56
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Case Report
Korean J Hematol 2006; 41(2): 129-133
Published online June 30, 2006 https://doi.org/10.5045/kjh.2006.41.2.129
Copyright © The Korean Society of Hematology.
TCL1 유전자 과발현을 보인 CD56 양성 T-세포 전림프구성 백혈병: 증례 및 문헌고찰
윤형기, 신명근, 김형준, 김혜란, 박지영, 조덕, 기승정, 김영휴, 신종희, 서순팔, 양동욱
전남대학교 의과대학 진단검사의학교실 및 화순전남대학교병원 진단검사의학과, 조혈계질환 유전체연구센터, 순천성가롤로병원 진단검사의학과
CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature
Hyeong Kee Yun, Myung Geun Shin, Hyeoung Joon Kim, Hye Ran Kim, Ji Young Park, Duck Cho, Seung Jung Kee, Young Hyu Kim, Jong Hee Shin, Soon Pal Suh, Dong Wook Ryang
Department of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital and, Genome Research Center for Hematopoietic Disease, Chonnam National University Hwasun Hospital, Sunchon St. Carollo Hospital, Hwasun, Korea
Abstract
T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis and an aggressive clinical course. We report here on a case of CD56+ T-PLL that was diagnosed by hematological examination, immunophenotyping and molecular studies including determining the TCL1 expression by using reverse-transcriptase polymerase chain reaction (RT-PCR), and direct sequencing of the RT-PCR product.
Keywords: T-cell Prolymphocytic Leukemia, TCL1, CD56
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