Korean J Hematol 1990; 25(1):
Published online March 31, 1990
© The Korean Society of Hematology
혈소판의 Plasminogen Activator Inhibitor 동태에 관한 연구
박선양, 이종석, 계경채, 이재훈, 김병국, 김노경, 고창순, 이문호
서울대학교 의과대학 내과학교실, 암연구소
Plasminogen Activator Inhibitor in Human Platelets
""Type 1 plasminogen activator inhibitor(PAI-1) in human platelets was studied. Total PAI-1 activity in normal platelets averaged 8.3±2.4 IU/10 9 platelets. The
active inhibitor activity was 2.8±1.1 IU/10 9 platelets represinging 33.7% of the total PAI-1 activity in the platelets. Stimulation with 0.2 U/㎖ α-thrombin released 81.9% of the inhibitor(6.8±2.7 IU/10 9 platelets) from the platelets. In the releasate, 32.4% of the inhibitor was present in the active from.
The relative ratio of PIA-1 antigen contained in the platelets to the amount in whole blood was 87.4% . The mean value for the platelet PAI-1 content in normal subjects
was 16.3±3.5 AU/10 9 platelets. In patients with clonal platelet disorders implicated with thrombotic and/or hemorrhagic tendency including chronic myelogenous
leukemia, polylcythemia vera, essential thrombocythemia, and paroxysmal nocturnal hemoglobinuria, platelet PAI-1 concentrations showed more variable distribution than in
normal subjects.
In the present study, we observed that most PAI-1 in human blood circulation was present in the platelets, and most in the latent form. Data on the release of PAI-1 after
α-thrombin stimulation suggested that the protein was secreted unchanged in the latent form. The possibility of conversion of the latent PAI-1 to the active form after release from the platelets remains to be elucidated.
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Korean J Hematol 1990; 25(1): 151-159
Published online March 31, 1990
Copyright © The Korean Society of Hematology.
혈소판의 Plasminogen Activator Inhibitor 동태에 관한 연구
박선양, 이종석, 계경채, 이재훈, 김병국, 김노경, 고창순, 이문호
서울대학교 의과대학 내과학교실, 암연구소
Plasminogen Activator Inhibitor in Human Platelets
Seonyang Park, Jong Suk Lee, Kyung Chae Kye, Jae Hoon Lee, Byoung Kook Kim, Noe Kyeong Kim, Chang Soon Koh, Munho Lee
Department of Internal Medicine and Cancer Research Institute College of Medicine, Seoul National University
Abstract
""Type 1 plasminogen activator inhibitor(PAI-1) in human platelets was studied. Total PAI-1 activity in normal platelets averaged 8.3±2.4 IU/10 9 platelets. The
active inhibitor activity was 2.8±1.1 IU/10 9 platelets represinging 33.7% of the total PAI-1 activity in the platelets. Stimulation with 0.2 U/㎖ α-thrombin released 81.9% of the inhibitor(6.8±2.7 IU/10 9 platelets) from the platelets. In the releasate, 32.4% of the inhibitor was present in the active from.
The relative ratio of PIA-1 antigen contained in the platelets to the amount in whole blood was 87.4% . The mean value for the platelet PAI-1 content in normal subjects
was 16.3±3.5 AU/10 9 platelets. In patients with clonal platelet disorders implicated with thrombotic and/or hemorrhagic tendency including chronic myelogenous
leukemia, polylcythemia vera, essential thrombocythemia, and paroxysmal nocturnal hemoglobinuria, platelet PAI-1 concentrations showed more variable distribution than in
normal subjects.
In the present study, we observed that most PAI-1 in human blood circulation was present in the platelets, and most in the latent form. Data on the release of PAI-1 after
α-thrombin stimulation suggested that the protein was secreted unchanged in the latent form. The possibility of conversion of the latent PAI-1 to the active form after release from the platelets remains to be elucidated.
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