Korean J Hematol 2005; 40(1):
Published online March 30, 2005
https://doi.org/10.5045/kjh.2005.40.1.15
© The Korean Society of Hematology
김삼용, 박상은, 박수진, 박남숙, 천재민, 박남환, 양영준, 윤각원, 윤환중, 김진만, 조덕연, 김삼용
충남대학교 의과대학 내과학교실, 병리학교실,
충남대학교 암공동연구소
Background: Biomarkers of lymphomas identified by immunostaining of lymphoma tissues were recently found to have a prognostic value for diffuse large B-cell lymphoma (DLBL). Thus, it seems likely that the prognostic prediction of lymphomas might be improved by incorporating biological markers into well known prognostic systems.
Methods: To determine the clinical significance of the biological markers expressed in DLBL, 26 patients, with de novo DLBL, were retrospectively studied at the Chungnam National University Hospital. Archival specimens from the patients were stained with antibodies for the bcl-2, bcl-6, Ki-67, CD 10, IRF-4, Granzyme-B, MHC-II and p16 antigens. Two immunophenotypic patterns of DLBL were identified by the pattern of differentiation; the germinal center (GC, CD10±/Bcl-6+/IRF-4-)-like subgroup and the post germinal center (pGC, CD10±/bcl-6±/IRF4+)-like subgroup.
Results: The median age of the subjects was 56 years, ranging form 37 to 69. After a median follow up duration of 48 months, the median survival time was 44 month, ranging from 1∼100 months. The five-year overall survival rate Using the Kaplan-Meier method was 32%. The only biomarker affecting the survival was bcl-2 (P=0.009). The survival of the GC-like subgroup was superior to that of the pGC-like subgroup, but without statistical significance (P=0.064). Among 18 patients with IPI scores 0∼2, those expressing bcl-2 (P=0.002) and the pGC-like subgroup had a worse prognosis compared to the GC-like subgroup (P=0.049).
Conclusion: The prognostic assessment of DLBL patients might be improved by the addition of immunohistochemical profiles, especially for bcl-2, to the traditional IPI system.
Keywords Diffuse large B-cell lymphoma, Bcl-2, Bcl-6, CD10, IRF-4, Germinal center subgroup
Korean J Hematol 2005; 40(1): 15-22
Published online March 30, 2005 https://doi.org/10.5045/kjh.2005.40.1.15
Copyright © The Korean Society of Hematology.
김삼용, 박상은, 박수진, 박남숙, 천재민, 박남환, 양영준, 윤각원, 윤환중, 김진만, 조덕연, 김삼용
충남대학교 의과대학 내과학교실, 병리학교실,
충남대학교 암공동연구소
Samyong Kim, Sang, Eun Park, Su, Jin Park, Nam, Suk Park, Jae, Min Chun, Nam, Whan Park, Yung, Jun Yang, Kak, Won Yun, Hwan, Jung Yun, Jin, Man Kim, Deogyeon Jo, Samyong Kim,
Departments of Internal Medicine, Pathology, College of Medicine
Cancer Research Institute, Chungnam National University, Daejeon, Korea
Background: Biomarkers of lymphomas identified by immunostaining of lymphoma tissues were recently found to have a prognostic value for diffuse large B-cell lymphoma (DLBL). Thus, it seems likely that the prognostic prediction of lymphomas might be improved by incorporating biological markers into well known prognostic systems.
Methods: To determine the clinical significance of the biological markers expressed in DLBL, 26 patients, with de novo DLBL, were retrospectively studied at the Chungnam National University Hospital. Archival specimens from the patients were stained with antibodies for the bcl-2, bcl-6, Ki-67, CD 10, IRF-4, Granzyme-B, MHC-II and p16 antigens. Two immunophenotypic patterns of DLBL were identified by the pattern of differentiation; the germinal center (GC, CD10±/Bcl-6+/IRF-4-)-like subgroup and the post germinal center (pGC, CD10±/bcl-6±/IRF4+)-like subgroup.
Results: The median age of the subjects was 56 years, ranging form 37 to 69. After a median follow up duration of 48 months, the median survival time was 44 month, ranging from 1∼100 months. The five-year overall survival rate Using the Kaplan-Meier method was 32%. The only biomarker affecting the survival was bcl-2 (P=0.009). The survival of the GC-like subgroup was superior to that of the pGC-like subgroup, but without statistical significance (P=0.064). Among 18 patients with IPI scores 0∼2, those expressing bcl-2 (P=0.002) and the pGC-like subgroup had a worse prognosis compared to the GC-like subgroup (P=0.049).
Conclusion: The prognostic assessment of DLBL patients might be improved by the addition of immunohistochemical profiles, especially for bcl-2, to the traditional IPI system.
Keywords: Diffuse large B-cell lymphoma, Bcl-2, Bcl-6, CD10, IRF-4, Germinal center subgroup
Jung Jun Bae, Yeo Soon Jang, Jung Yun Kim, Yeon Jung Lim, Hyun Kyung Park, Jin Yeong Han, Young Ho Lee
Korean J Hematol 2007; 42(3): 206-215Xiaobo Liu, Yanliang Bai, Ying Liu, Weiya Li, Yabin Cui, Jinhui Xu, Xingjun Xiao, Xiaona Niu, Kai Sun
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