A Case of Vancomycin-Induced Thrombocytopenia

Jae Hyeon Lee; Dal Sik Kim; Hye Soo Lee; Sam Im Choi; Yong Gon Cho

doi:10.5045/kjh.2009.44.4.294

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Case Report

Korean J Hematol 2009; 44(4):

Published online December 30, 2009

https://doi.org/10.5045/kjh.2009.44.4.294

반코 마이신을 이용한 Thrombocytopenia

이재현, 김달식, 이혜수, 최삼임, 조용곤

전북대학 의과대학 임상연구소 진단감사의학과

A Case of Vancomycin-Induced Thrombocytopenia

Jae Hyeon Lee, Dal Sik Kim, Hye Soo Lee, Sam Im Choi, Yong Gon Cho

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Department of Laboratory Medicine, Chonbuk National University Medical School,Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea

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Abstract

Immune thrombocytopenia is a rare complication associated with vancomycin. A 76-year-old male patient who was treated with vancomycin experienced severe thrombocytopenia and refractoriness as a result of platelet transfusion. Vancomycin-dependent antibodies in his thrombocytopenic serum were detected by flow cytometric analysis. The mechanism of thrombocytopenia is probably related to immunological destruction, as strongly suggested by its association with a specific drug-dependent anti-platelet antibody. (Korean J Hematol 2009;44:294-297.)

Keywords Thrombocytopenia, Vancomycin, Drug-induced

Article

Case Report

Korean J Hematol 2009; 44(4): 294-297

Published online December 30, 2009 https://doi.org/10.5045/kjh.2009.44.4.294

반코 마이신을 이용한 Thrombocytopenia

이재현, 김달식, 이혜수, 최삼임, 조용곤

전북대학 의과대학 임상연구소 진단감사의학과

A Case of Vancomycin-Induced Thrombocytopenia

Jae Hyeon Lee, Dal Sik Kim, Hye Soo Lee, Sam Im Choi, Yong Gon Cho

Department of Laboratory Medicine, Chonbuk National University Medical School,Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea