Angioimmunoblastic T-cell lymphoma" />
Korean J Hematol 2008; 43(3):
Published online September 30, 2008
https://doi.org/10.5045/kjh.2008.43.3.174
© The Korean Society of Hematology
최윤희 김효석 남승범 강혜진 나임일 양성현 류백렬
원자력병원 내과
Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL.
Keywords Angioimmunoblastic T-cell lymphoma, Diffuse large B-cell lymphoma, Epstein-Barr virus
Korean J Hematol 2008; 43(3): 174-178
Published online September 30, 2008 https://doi.org/10.5045/kjh.2008.43.3.174
Copyright © The Korean Society of Hematology.
최윤희 김효석 남승범 강혜진 나임일 양성현 류백렬
원자력병원 내과
Yoon Hee Choi, Hyo Seog Kim, Seung Bum Nam, Hye Jin Kang, Im Il Na, Sung Hyun Yang, Baek-Yeol Ryoo
Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea
Angioimmunoblastic T-cell lymphoma (AITL) is a systemic lymphoproliferative disorder that presents with profound immune dysfunction and immunodeficiency. As in many other immunodeficiencies, Epstein-Barr virus (EBV) associated B-cell lymphoid proliferation can occur in AITL but few cases of EBV-positive B-cell lymphoma have been reported in patients with preexisting AITL. We report a case of AITL in which EBV-positive diffuse large B-cell lymphoma (DLBCL) developed 13 months after the initial diagnosis of AITL. Although the exact mechanisms remain unclear, Epstein-Barr virus may have played a role in the pathogenesis of the secondary DLBCL.
Keywords: Angioimmunoblastic T-cell lymphoma, Diffuse large B-cell lymphoma, Epstein-Barr virus
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