Korean J Hematol 2007; 42(3):
Published online September 30, 2007
https://doi.org/10.5045/kjh.2007.42.3.283
© The Korean Society of Hematology
조재현, 최원섭, 허경림, 원지언, 이영경, 장대영, 김효정
한림대학교 의과대학 내과학교실, 진단검사의학교실
Human parvovirus B19 infection could be manifested as pure red cell aplasia or chronic anemia in immunocompromised host. The patient was 35-year-old female who had been diagnosed as non-Hodgkin lymphoma, peripheral T-cell unspecified type and had been performed chemotherapy. She complained headache and dizziness that was found to a marked drop in hemoglobin (3.2g/dL). A bone marrow aspiration revealed findings consistent with erythroid hypoplasia with maturation arrest. Serum parvovirus B19 PCR and anti parvovirus B19 IgM were positive. After immunoglobulin therapy, it was leading to a marked increase in reticulocyte count and corresponding rise in hemoglobin. To our knowledge, this is the first report to use immunoglobulin in an adult cancer patient with pure red-cell aplasia. Human parvovirus B19 infection should be considered in immunocompromised cancer patients with red cell aplasia and early use of immunoglobulins would be helpful in resolution of anemia and not to delay planned chemotherapy.
Keywords Human parvovirus B19, Pure red-cell aplasia, Immunoglobulins
Korean J Hematol 2007; 42(3): 283-287
Published online September 30, 2007 https://doi.org/10.5045/kjh.2007.42.3.283
Copyright © The Korean Society of Hematology.
조재현, 최원섭, 허경림, 원지언, 이영경, 장대영, 김효정
한림대학교 의과대학 내과학교실, 진단검사의학교실
Jae Hyun Cho, Won Sub Choi, Kyung Rim Huh, Ji Eon Won, Young Kyung Lee, Dae Young Zang, Hyo Jung Kim
Departments of Internal Medicine, Laboratory Medicine, College of Medicine, Hallym University, Chuncheon, Korea
Human parvovirus B19 infection could be manifested as pure red cell aplasia or chronic anemia in immunocompromised host. The patient was 35-year-old female who had been diagnosed as non-Hodgkin lymphoma, peripheral T-cell unspecified type and had been performed chemotherapy. She complained headache and dizziness that was found to a marked drop in hemoglobin (3.2g/dL). A bone marrow aspiration revealed findings consistent with erythroid hypoplasia with maturation arrest. Serum parvovirus B19 PCR and anti parvovirus B19 IgM were positive. After immunoglobulin therapy, it was leading to a marked increase in reticulocyte count and corresponding rise in hemoglobin. To our knowledge, this is the first report to use immunoglobulin in an adult cancer patient with pure red-cell aplasia. Human parvovirus B19 infection should be considered in immunocompromised cancer patients with red cell aplasia and early use of immunoglobulins would be helpful in resolution of anemia and not to delay planned chemotherapy.
Keywords: Human parvovirus B19, Pure red-cell aplasia, Immunoglobulins
Eun Sil Park, Hye Young Han, Jae Young Lim, Sung Sup Park, Sun Young Kim
Korean J Hematol 2009; 44(3): 153-156