Korean J Hematol 2001; 36(4):
Published online December 31, 2001
© The Korean Society of Hematology
일차성 위장관 비호지킨림프종의 임상적 고찰 및 Ann Arbor 및 Musshoff 병기분류의 의의에 관한 후향적 연구
서광운, 김동환, 성우진, 박성원, 김종광, 정진태, 박태인, 김세환, 신동건, 손상균, 이규보
경북대학교 의과대학 내과학교실,
경북대학교 의과대학 병리학교실,
대구파티마병원 내과,
암연구소
The Clinical Significance of Ann Arbor and Musshoff's Staging System in Primary Gastrointestinal Non-Hodgkin's Lymphoma-A Retrospective Analysis
Background:
Primary Gastrointestinal Non-Hodgkin's Lymphoma (GIL) represents 4 to 20% of all Non-Hodgkin's Lymphoma(NHL) and gastrointestinal tract(GIT) is the most frequently involved extranodal site in NHL. It is known that the prognosis
of GIL is better than that of other NHLs because of it's unique biologic behavior and anatomical location. We reviewed clinical astects of GIL and analyzed survival data based on Ann-Arbor and Musshoff's staging system.
Methods:
Sixty six cases were analyzed by age, sex, clinical manifestaion, location, histology, clinical course, and two staging systems (Ann Arbor and Musshoff's modified staging). Histologies were reviewed according to REAL classification.
Results:
The median age was 51.5 years. The most frequent gross finding was ulcerofungating lesion in upper GIL and mass lesion in lower GIL. Treatment results were as following : 76.9% of response rate, 59.5% of 5-year overall survival rate, and 54.8% of 5-year disease free survival rate. There was a significant difference of overall survival or disease free survival rate between group below stage IIE1 and above IIE2 according to Musshoff's staging system. There were no significant differences in survival between stage Ⅰ and
Ⅱ, and between stage Ⅲ and Ⅳ based on Ann Arbor staging system.
Conclusion:
There might be the necessity of discriminating localized disease (IIE1) and locally advanced lesion (IIE2) to predict the prognosis of GIL through Musshoff's staging
system. Larger study will be needed to confirm the role of Musshoff's staging system.
Keywords Primary Gastrointestinal Lymphoma, Musshoff's modified staging system, Ann Arbor staging system
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Korean J Hematol 2001; 36(4): 275-285
Published online December 31, 2001
Copyright © The Korean Society of Hematology.
일차성 위장관 비호지킨림프종의 임상적 고찰 및 Ann Arbor 및 Musshoff 병기분류의 의의에 관한 후향적 연구
서광운, 김동환, 성우진, 박성원, 김종광, 정진태, 박태인, 김세환, 신동건, 손상균, 이규보
경북대학교 의과대학 내과학교실,
경북대학교 의과대학 병리학교실,
대구파티마병원 내과,
암연구소
The Clinical Significance of Ann Arbor and Musshoff's Staging System in Primary Gastrointestinal Non-Hodgkin's Lymphoma-A Retrospective Analysis
Kwang Woon Seo, Dong Hwan Kim, Woo Jin Sung, Sung Won Park, Jong Gwang Kim, Jin Tae Jung, Tae In Park, Se Hwan Kim, Dong Gun Shin, Sang Kyun Sohn, Kyu Bo Lee
Department of Internal Medicine, Pathology, Cancer Research Institute Kyungpook National University, School of Meidcine, Taegu, Korea
Abstract
Background:
Primary Gastrointestinal Non-Hodgkin's Lymphoma (GIL) represents 4 to 20% of all Non-Hodgkin's Lymphoma(NHL) and gastrointestinal tract(GIT) is the most frequently involved extranodal site in NHL. It is known that the prognosis
of GIL is better than that of other NHLs because of it's unique biologic behavior and anatomical location. We reviewed clinical astects of GIL and analyzed survival data based on Ann-Arbor and Musshoff's staging system.
Methods:
Sixty six cases were analyzed by age, sex, clinical manifestaion, location, histology, clinical course, and two staging systems (Ann Arbor and Musshoff's modified staging). Histologies were reviewed according to REAL classification.
Results:
The median age was 51.5 years. The most frequent gross finding was ulcerofungating lesion in upper GIL and mass lesion in lower GIL. Treatment results were as following : 76.9% of response rate, 59.5% of 5-year overall survival rate, and 54.8% of 5-year disease free survival rate. There was a significant difference of overall survival or disease free survival rate between group below stage IIE1 and above IIE2 according to Musshoff's staging system. There were no significant differences in survival between stage Ⅰ and
Ⅱ, and between stage Ⅲ and Ⅳ based on Ann Arbor staging system.
Conclusion:
There might be the necessity of discriminating localized disease (IIE1) and locally advanced lesion (IIE2) to predict the prognosis of GIL through Musshoff's staging
system. Larger study will be needed to confirm the role of Musshoff's staging system.
Keywords: Primary Gastrointestinal Lymphoma, Musshoff's modified staging system, Ann Arbor staging system
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