Korean J Hematol 2007; 42(2):
Published online June 30, 2007
https://doi.org/10.5045/kjh.2007.42.2.167
© The Korean Society of Hematology
이성윤, 김효송, 전현정, 양지현, 고영혜, 기창석, 김원석
성균관대학교 의과대학 삼성서울병원, 내과, 병리과, 진단검사의학과
Epstein-Barr virus (EBV) infection is associated with various lymphoproliferative diseases, including Hodgkin lymphoma, extranodal NK/T cell lymphoma, aggressive NK cell leukemia, Burkitt lymphoma and post-transplant lymphoproliferative disorder. In the recent studies, the plasma EBV-DNA levels in patients with EBV-associated lymphoproliferative disease appeared to be correlated with the therapeutic response. Aggressive NK cell leukemia (ANKL) is a fatal disease that's characterized by high fever, lymphadenopathy, hepatosplenomegaly and frequent hemophagocytosis. No serological tumor marker for this malignancy has yet been identified for monitoring the disease and predicting the outcome. We experienced a case of aggressive natural killer cell leukemia in a 48-year-old man, and we serially monitored the plasma EBV DNA load by performing real time quantitative PCR assay. Serial measurements of the plasma EBV DNA level during therapy showed a close correlation between the clinical response and the changes in the plasma EBV DNA titers.
Keywords Aggressive natural killer cell leukemia (ANKL), Epstein Barr virus (EBV), Real time quantitative PCR
Korean J Hematol 2007; 42(2): 167-171
Published online June 30, 2007 https://doi.org/10.5045/kjh.2007.42.2.167
Copyright © The Korean Society of Hematology.
이성윤, 김효송, 전현정, 양지현, 고영혜, 기창석, 김원석
성균관대학교 의과대학 삼성서울병원, 내과, 병리과, 진단검사의학과
Seong Yoon Yi, Hyo Song Kim, Hyun Jung Jun, Ji Hyun Yang, Young H. Ko, Chang, Seok Ki, Won Seog Kim
Departments of, Internal Medicine, Pathology, Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Epstein-Barr virus (EBV) infection is associated with various lymphoproliferative diseases, including Hodgkin lymphoma, extranodal NK/T cell lymphoma, aggressive NK cell leukemia, Burkitt lymphoma and post-transplant lymphoproliferative disorder. In the recent studies, the plasma EBV-DNA levels in patients with EBV-associated lymphoproliferative disease appeared to be correlated with the therapeutic response. Aggressive NK cell leukemia (ANKL) is a fatal disease that's characterized by high fever, lymphadenopathy, hepatosplenomegaly and frequent hemophagocytosis. No serological tumor marker for this malignancy has yet been identified for monitoring the disease and predicting the outcome. We experienced a case of aggressive natural killer cell leukemia in a 48-year-old man, and we serially monitored the plasma EBV DNA load by performing real time quantitative PCR assay. Serial measurements of the plasma EBV DNA level during therapy showed a close correlation between the clinical response and the changes in the plasma EBV DNA titers.
Keywords: Aggressive natural killer cell leukemia (ANKL), Epstein Barr virus (EBV), Real time quantitative PCR