Korean J Hematol 1998; 33(3):
Published online September 30, 1998
© The Korean Society of Hematology
성인 급성 골수성 백혈병의 관해유도치료에서 AD 복합화학요법의 치료효과
김성목, 이상엽, 김병덕, 이은정, 이경희, 현명수
영남대학교 의과대학 내과학교실
Effect of Remission Induction Chemotherapy with AD(Cytosine Arabinoside, Daunorubicin) in Adult Acute Myelogenous Leukemia
Background: The goal of acute myelogenous leukemia(AML) therapy is to obtain the complete remission(CR) and to improve disease-free survival. Advances in chemotherapy
and supportive care provided significant improvement in CR rate up to 60∼85% patients with AML.
Methods: Forty two patients with previously untreated AML at Yeung Nam University Hospital from April 1985 through November 1996 were treated with AD(7-3) regimen for induction chemotherapy and followed by two courses of consolidation with AD(5-2) regimen. And the authors analyzed clinical factors related to the CR and
overall survival.
Results: Twenty-four of the 42 patients achieved CR, and median duration of remission in 24 patients achieved CR was 56 weeks(4∼ 305 +weeks). Median duration of survival in all 42 cases was 46 weeks(2∼340 + weeks), and in 24 cases achieved CR was 73 weeks(12∼340 +weeks). Causes of induction failure included infection in 9 cases, bleeding in 3 cases and drug resistance in 6 cases. Among the potential prognostic variables including age, initial WBC count,
performance status, and presence of Auer rods and infection at the time of diagnosis, none was statistically significantly related to the prognosis.
Conclusion: Further clinical trials for effective remission induction and postremission chemotherapy are necessary to overcome drug resistance and to increase the CR rate and duration.
Keywords Acute Myelogenous Leukemia; AD Chemotherapy; Remission rate; Survival rate;
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Korean J Hematol 1998; 33(3): 353-362
Published online September 30, 1998
Copyright © The Korean Society of Hematology.
성인 급성 골수성 백혈병의 관해유도치료에서 AD 복합화학요법의 치료효과
김성목, 이상엽, 김병덕, 이은정, 이경희, 현명수
영남대학교 의과대학 내과학교실
Effect of Remission Induction Chemotherapy with AD(Cytosine Arabinoside, Daunorubicin) in Adult Acute Myelogenous Leukemia
Sung Mok Kim, Sang Yeop Lee, Byeong Duk Kim, Eun Jung Lee, Kyeong Hee Lee, Myung Su Hyun
Department of Internal Medicine, College of Medicine, Yeung Nam University, TaeGu, Korea
Abstract
Background: The goal of acute myelogenous leukemia(AML) therapy is to obtain the complete remission(CR) and to improve disease-free survival. Advances in chemotherapy
and supportive care provided significant improvement in CR rate up to 60∼85% patients with AML.
Methods: Forty two patients with previously untreated AML at Yeung Nam University Hospital from April 1985 through November 1996 were treated with AD(7-3) regimen for induction chemotherapy and followed by two courses of consolidation with AD(5-2) regimen. And the authors analyzed clinical factors related to the CR and
overall survival.
Results: Twenty-four of the 42 patients achieved CR, and median duration of remission in 24 patients achieved CR was 56 weeks(4∼ 305 +weeks). Median duration of survival in all 42 cases was 46 weeks(2∼340 + weeks), and in 24 cases achieved CR was 73 weeks(12∼340 +weeks). Causes of induction failure included infection in 9 cases, bleeding in 3 cases and drug resistance in 6 cases. Among the potential prognostic variables including age, initial WBC count,
performance status, and presence of Auer rods and infection at the time of diagnosis, none was statistically significantly related to the prognosis.
Conclusion: Further clinical trials for effective remission induction and postremission chemotherapy are necessary to overcome drug resistance and to increase the CR rate and duration.
Keywords: Acute Myelogenous Leukemia, AD Chemotherapy, Remission rate, Survival rate,
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