The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult

Yan Xie; Valeria Visconte; Lei Duan; Heesun J. Rogers

doi:10.5045/br.2018.53.2.163

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Letter to the Editor

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Blood Res 2018; 53(2):

Published online June 25, 2018

https://doi.org/10.5045/br.2018.53.2.163

The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult

Yan Xie¹, Valeria Visconte², Lei Duan³, and Heesun J. Rogers^1*

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¹Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

³Department of Pathology, Southern New Hampshire Medical Center, Nashua, NH, USA.

Correspondence to : Heesun J. Rogers. Section of Hematopathology Department of Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue L-30 Cleveland, OH 44195, USA. rogersj5@ccf.org

Received: September 21, 2017; Accepted: November 24, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article

Letter to the Editor

Blood Res 2018; 53(2): 163-166

Published online June 25, 2018 https://doi.org/10.5045/br.2018.53.2.163

The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult

Yan Xie¹, Valeria Visconte², Lei Duan³, and Heesun J. Rogers^1*

¹Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

³Department of Pathology, Southern New Hampshire Medical Center, Nashua, NH, USA.

Correspondence to:Heesun J. Rogers. Section of Hematopathology Department of Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue L-30 Cleveland, OH 44195, USA. rogersj5@ccf.org

Received: September 21, 2017; Accepted: November 24, 2017

Fig 1.

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Figure 1.Bone marrow (BM) histopathologic and cytogenetic findings at diagnosis. (A, B) BM aspirate and biopsy showed left-shifted granulocytic hyperplasia with a high myeloid:erythroid ratio and megakaryocytes with small hypolobated (dwarf) forms (A: Wright-Giemsa stain, ×1,000, B: hematoxylin and eosin stain, ×400). (C) The composite pictures from the aspirate smears showed small single or multiple ring-form organisms within the erythrocytes. One of the erythrocytes in the left lower part showed the stage occurring after the breakdown of the classic tetrad (“Maltese cross”) (Wright-Giemsa stain, ×1,000). (D) Fluorescent in-situ hybridization in BM specimen using tri-color dual fusion probes (BCR/ABL1/ASS1) demonstrated BCR/ABL1 translocation (red-green fusion) in 3 interphase cells. ABL1 and ASS1 probes in chromosome 9q34 region and BCR probe in chromosome 22q11.2 region showed red, aqua, and green signals, respectively (Abbott Molecular, Abbott Park, IL).

Blood Research 2018; 53: 163-166https://doi.org/10.5045/br.2018.53.2.163