Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature

Pulkit Rastogi; Preethi Jeyaraman; Man Updesh Sachdeva; Pankaj Malhotra; Jasmina Ahluwalia

doi:10.5045/br.2018.53.2.160

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Letter to the Editor

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Blood Res 2018; 53(2):

Published online June 25, 2018

https://doi.org/10.5045/br.2018.53.2.160

Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature

Pulkit Rastogi¹, Preethi Jeyaraman², Man Updesh Sachdeva¹, Pankaj Malhotra², and Jasmina Ahluwalia^1*

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¹Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

²Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Correspondence to : Jasmina Ahluwalia. Department of Hematology, Postgraduate Institute of Medical Education and Research, 5th Floor, Research Block A, Chandigarh, 160012 India. japgi@live.com, jasminapgi@gmail.com

Received: September 25, 2017; Revised: October 20, 2017; Accepted: November 13, 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Letter to the Editor

Blood Res 2018; 53(2): 160-163

Published online June 25, 2018 https://doi.org/10.5045/br.2018.53.2.160

Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature

Pulkit Rastogi¹, Preethi Jeyaraman², Man Updesh Sachdeva¹, Pankaj Malhotra², and Jasmina Ahluwalia^1*

¹Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

²Department of Internal Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Correspondence to:Jasmina Ahluwalia. Department of Hematology, Postgraduate Institute of Medical Education and Research, 5th Floor, Research Block A, Chandigarh, 160012 India. japgi@live.com, jasminapgi@gmail.com

Received: September 25, 2017; Revised: October 20, 2017; Accepted: November 13, 2017

Fig 1.

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Figure 1.Morphological and immunophenotypic findings of the neoplastic cells. (A) Peripheral blood smear showing a typical “hairy” cell (May-Grunwald Giemsa stain, ×1,000). (B) Trephine biopsy showing predominantly “hairy” cells with fried egg appearance and an interstitial nodule of mature appearing lymphoid cells (H & E stain, x600). (C, D) Immunohistochemistry for CD5 and CD23 respectively showing positivity in interstitial nodules of lymphoid cells (Hematoxylin counterstain, ×400). (E, F) Immunohistochemistry for CD20 and DBA.44 highlighting the “hairy” cells and negative in lymphoid nodule (Hematoxylin counterstain, ×400).

Blood Research 2018; 53: 160-163https://doi.org/10.5045/br.2018.53.2.160

Fig 2.

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Figure 2.Immunophenotyping of the neoplastic cells in bone marrow aspirate at the time of diagnosis by four-color flow cytometry (dot-plot analysis). CLL/SLL cells (sky-blue) showing characteristic phenotype: CD5+, CD23+, sIgweak+, CD20weak+ and CD10- whereas HCL cells (purple) showing CD20bright+, CD25+, CD103+, CD11cbright+, sIg+, CD23-, CD5-, and CD10-.

Blood Research 2018; 53: 160-163https://doi.org/10.5045/br.2018.53.2.160

Table 1 . .

Clinicopathologic characteristics of patients with synchronous HCL and CLL/SLL..