Patient: Mortality after receiving blood transfusion, iron pharmacological preparations and role of NTBI and LPI.
Setting: review of studies; RCT; animal preclinical studies; a)population studies.
Interventions: role of TS, NTBI, and LPI in patient mortality in iron overload conditions, multi-transfused patients; iron pharmacological preparations.
Comparison: The NTBI, LPI increase during the RBC transfusions; hemolytic anemia; multi-transfusion anemia patients; iron formulations.
a)Animal preclinical studies were awarded moderate or below grading.
Abbreviations: DCI, directly chelatable iron; LPI, labile plasma iron; NTBI, non transferrin bound iron; ROS, reactive oxygen species; TS, transferrin saturation.