Patient: Role of TS, NTBI, LPI in patient's mortality after receiving blood transfusion.

Setting: Review of studies; RCT; animal preclinical studies^a); Population studies^b).

Interventions: The NTBI, LPI release in the RBC transfusions; hemolytic anemia; stored RBC units.

^a)Review studies awarded moderate grading. ^b)Animal experimentation awarded moderate grading.

Abbreviations: LPI, labile plasma iron; NTBI, non transferrin bound iron; ROS, reactive oxygen species; TS, transferrin saturation.