Der f-sNOI and Der f-sΔFSC according to the Der f-sIgG level. The relationship between Der f-sIgG levels and (A) NOI; (B) 1/NOI (P<0.05); and (C) ΔFSC (P=0.201). The red and blue arrows indicate extreme cases of Der f-sIgG levels (highest and lowest, respectively). In panel B, the case with the lowest (undetectable) Der f-sIgG levels (73-year-old woman, potential non-responder against Der f) was excluded from the regression analysis.