Abbreviations: BM, bone marrow; GIT, gastrointestinal tract; LN, lymph node; LPL, lymphoplasmacytic lymphoma; OS, overall survival; BR, bendamustine+rituximab; R, rituximab; CHOP, cyclophosphamide+doxorubicin+vincristine+prednisolone; C(V)P, cyclophosphamide+(vincristine)+prednisolone; FDR, fludarabine; HD-dex, high-dose dexamethasone; HD-MA, high-dose methotrexate+ara-C; ICE-dex, ifosfamide+carboplatin+etoposide+dexamethasone; MP, melphalan+prednisolone; VAD, vincristine+doxorubicin+dexamethasone; VMP, bortezomib+melphalan+prednisolone; ISSWM, International Prognostic Scoring System for Waldenstrom Macroglobulinemia; Int, Intermediate; CR, complete response; PR, partial response; MR, minimal response; SD, stable disease; PD, progressive disease.