MRI changes in the lymphoma lesion during chemotherapy. Prior to receiving chemotherapy, the size of the frontal lesion was approximately 4.1 cm with perilesional edema and midline shifting to the right side (A). After the fourth cycle of chemotherapy, partial remission was achieved, with decrease in tumor size to approximately 2.1 cm with perilesional edema as well as disappearance of midline shifting (B). After the sixth cycle of chemotherapy, the tumor further decreased to 1.8 cm with perilesional edema (C). After undergoing ASCT, the patient achieved CR (D).