Reduction of transfusion requirement after eculizumab. The mean number of packed RBC units transfused was significantly reduced from 8.5 units during the 6 months prior to initiation of eculizumab to 1.6 units in the first 6 months of treatment, for the total study population. P-values compared with baseline were assessed by Wilcoxon signed-rank test.

Abbreviations: AA, aplastic anemia; ecu, eculizumab; PNH, paroxysmal nocturnal hemoglobinuria; RBC, red blood cells.