Analysis of promoter methylation and expression of genes encoding hematopoietic TFs in pediatric patients with B-cell ALL. (A) Comparison of promoter methylation levels of HOXA4, HOXA5, MEIS1, IRF4, IRF8, and TAL1 in samples from patients with ALL and controls. (B) Comparison of expression levels of HOXA4, HOXA5, MEIS1, IRF4, IRF8, and TAL1 in samples from patients with ALL and control. (C) Comparison of TAL1 methylation level in patients aged 1-9 years and those aged >10 years. (D) Comparison of TAL1 methylation level in patients who experienced and did not experience relapse. (E) Comparison of HOXA4 expression level in patients with ALL showing intermediate and high risk according to NCI risk classification. (F) Correlation between MEIS1 expression level and WBC count in patients with ALL. Horizontal lines indicate median value.