^a)History of hemorrhagic stroke or stroke of unknown origin; intracranial tumor; ischemic stroke within 3 months; history of major trauma, surgery or head injury within 3 weeks; platelets <100,000/µL; active bleeding; bleeding diathesis. ^b)Recent CNS bleed; intracranial or spinal lesion at high risk for bleeding; active bleeding with more than 2 units transfused in 24 hours.

Abbreviations: BP, blood pressure; CNS, central nervous system; DVT, deep vein thrombosis; IVC, inferior vena cava; PTE, pulmonary thromboembolism.